摘要
目的 研究和比较他克莫司 (FK5 0 6 )以及环孢素A(CsA)对肾移植术后患者肝功能的影响。方法 将肾移植术后患者随机分为FK5 0 6组和CsA组 ,FK5 0 6组 8例 ,CsA组 2 6例。CsA组中出现肝功能异常的 6例患者用FK5 0 6进行替换治疗。两组均联合应用霉酚酸酯 (MMF)和泼尼松(Pred)。结果 观察 6个月 ,FK5 0 6组和CsA组中急性排斥的发生率差异不显著 ;FK5 0 6组中未发现肝功能异常患者 ,CsA组中有 6例患者肝功能异常 ;肝功能异常的 6例患者用FK5 0 6替换CsA后 ,总胆红素 (TBIL)、直接胆红素 (DBIL)、丙氨酸转氨酶 (ALT)相继转为正常。结论 FK5 0 6免疫抑制效果与CsA相似 ,但对肝功能影响甚微 。
ObjectiveTo investigate the effect of FK506 and CsA comparatively on hepatic function of renal transplant recipients. Methods FK506 and CsA were used respectively as a post operative immunosuppressant for 8 and 26 cases of renal transplantation. In the CsA treated group, 6 cases of hepatic dysfunction were conversed to FK506. Both two groups took MMF and prednisone. Results During the period of observation, there was no significant difference between FK506 and CsA in acute rejection incidence. Comparing to FK506 group with no case of hepatic dysfunction, hepatic dysfunction occurred in 6 cases who conversed to FK506, and liver function returned normal gradually in the CsA group. Conclusion It is effective and safe to substitute CsA by FK506 combined with MMF in renal transplant recipients with hepatic dysfunction after renal transplantation.
出处
《中华器官移植杂志》
CAS
CSCD
北大核心
2001年第6期364-365,共2页
Chinese Journal of Organ Transplantation
