摘要
目的 :观察青少年特发性脊柱侧弯 (AIS)患者椎旁肌中肌梭的变化 ,以明确其在AIS发生、发展中的作用 ,为预防及治疗AIS提供理论依据。方法 :对 2 2例AIS患者及 4例尸体对照中椎旁肌中肌梭的数目、密度、分布进行了观察。结果 :AIS患者中肌梭密度明显低于对照组。肌梭的病变在Cobb角 >5 0°的患者中比较常见。肌梭数同侧弯度数及取材部位无关。结论 :AIS的病理变化是一个连续的渐进过程 ,应适早行手术治疗 。
Objective: To study the etiology and pathological process of adolescent idiopathic scoliosis.Methods:The quantity and quality of the muscle spindles in paraspinal muscle biopsy samples taken from 22 AIS patients and 4 adolescent specimens were examined by microscope.Results:The number of muscle spindles in AIS patients is significantly fewer than in normal specimen,Pathological changes of muscle spindles were found in some AIS patients,the change appeared to be worse in patients with Cobb's angle more than 50 degrees.The muscle spindles in adolescent specimen were normal.The number of muscle spindles is not related to the degree of scoliotic curve and the sites of muscle samples.Conclusion:AIS was a continuous process,the pathological structure changes of muscle spindles were secondary to adaptations of abnormal growth of the spine.AIS patients need early operations to break this patho dynamic/vicious cycle.
出处
《中国矫形外科杂志》
CAS
CSCD
2001年第9期841-843,T002,共4页
Orthopedic Journal of China
