摘要
目的 研究模拟微重力 (SM)时大小循环动脉血管舒张反应性随时间变化的过程 ,为SM时大小循环血管局部调节的适应机理和立位耐力降低机理的研究积累资料。 方法 采用 - 30°尾部悬吊大鼠模型模拟微重力的生理效应 ,研究对照组 (CON组 )、悬吊 7d组 (TS7组 )和悬吊 14d组(TS14组 )离体灌流的胸主动脉 (TA)和肺动脉 (PA)环的反应性。 结果 TS7组 TA和 PA舒张反应显著增强 ;TS14组 PA反应有减弱趋势而 TA仍有增强。去内皮 PA对硝普钠的舒张反应 3组间无显著性意义。 结论 模拟微重力时大小循环动脉舒张反应的不同变化 ,是局部调节功能降低的表现 ,可能对
Objective To investigate the dynamic changes of d ilatory reactivity(DR) of thoracic aorta(TA) and pulmonary arteries(PA) in the course of simulated microgravity so that to gather data for researches on mechan ism of local regulation of systematic and pulmonary circulation and mechanism of orthostatic intolerance. Methods Tail suspension(-30°) was u sed to simulate microgravity. The DR of TA and PA from rats of control group(CO N), 7 d tail suspension group (TS7) and 14 d tail suspension group (TS14) were observed in vitro by vessel ring perfusion technique. Results As compared with that of CON, the DR of TA and PA increased significantly in TS7 rats, while in TS14 rats, the DR of TA increased slightly, but the DR of PA dec reased significantly. The differences of DR of PA to sodium nitroprussiate among rats of 3 groups with endothelium removed were non-significant. Concl usion The difference of effects of microgravity on the DR of systematic circulation and pulmonary circulation may be an important sign of lowering of l ocal regulation function and contribute to the occurrence of orthostatic intoler ance after simulated microgravity.
出处
《中华航空航天医学杂志》
CSCD
2001年第3期145-149,共5页
Chinese Journal of Aerospace Medicine
关键词
模拟微重力
胸主动脉
肺动脉
舒张反应性
立位耐力
Simulated microgravity
Thoracic aorta
Pulmonary artery
Dilatory reactivity
Orthostatic tolerance
