摘要
目的:观察国产1％萘替芬软膏治疗浅部真菌病的疗效和药物不良反应。方法:选择99例临床浅部真菌病患者,随机分为双盲对照组和开放组进行1％萘替芬软膏和3％克霉唑软膏的临床疗效、真菌学疗效及不良反应的对照观察;二者均为每日两次,直接涂于患处;其中体、股癣、花斑癣和皮肤念珠菌病连续用药2周;手、足癣连续用药4周。结果:1％萘替芬软膏和3％克霉唑软膏治疗浅部真菌病均有良好的疗效,其中停药时萘替芬和霉唑的治愈率为65％和38.89％(P>0.05),有效率为90％和72.22(P>0.05)。停药2周后萘替芬和克霉唑的治愈率为90％和66.67％(P>0.05),有效率为95％和100.00(P>0.05)。结论:萘替芬软膏是一种广谱、高效、低毒,并有较好耐受性的新型抗真菌药。
Objective: The aim of this study is to assess the efficacy and safety of 1 % naftifine cream in the treatment of dermatophy-toses. Methods: A randomized double blind controlled and open clinical trails were performed, 3% clotrimazole cream was chosen as the control. 99 patients with dermatophytoses were randomly divide into naftifine cream group and clotrimazole cream group, both clinical and mycological efficacy were evaluate by clinical manifestation, mycoses efficacy and their adverse drug reaction. Applied twice daily for 2 weeks in the treatment of tinea corporis, tinea cruris, tinea versicolor, and cutaneous candidiasis. and for 4 weeks in the treament of tinea pedis and tinea manuum. Results: When stop use drug the curative rate of naftifine and clotrimazole group were 65% and 38.89%(P> 0.05), the total effective rates was 90% and 72.22(P> 0.05), respectively. The curative rate of naftifine and clotrimazole group were 90% and 66.67%(P> 0.05) , the total effective rates was 95% and 100.00(P> 0.05) , respectively, at the follow up two weeks. Conclusion: Naftifine cream is the novel kind of general antimycotic agent; it is higher efficacy and safety drug for the treatment of dermatomycoses.
出处
《中国医药导刊》
2001年第4期282-284,共3页
Chinese Journal of Medicinal Guide
