摘要
埃本膦酸盐属二膦酸盐类药物,它可以阻止钙从骨质中过量释放(骨质溶解/破坏),并使血液中升高的钙水平正常化。临床上主要用于治疗肿瘤骨转移所致的高血钙、Paget's疾病、交变性骨炎、异位骨化和骨质疏松等。它是目前开发出的毒副作用少、疗效最强的二膦酸盐类药物之一。本文综合近年来的有关文献,对埃本膦酸盐的研究进展作一综述。
Ibandronate (ibandronic acid) is a third generation bisphosphonate. It can significantly reduce albumin - corrected serum calcium levels and urinary marks of bone resorption in patients with hypercalcaemia of malignancy, and in those with bone metas-tases. Ibandronate has been shown to be clinically effective in patients with tumour - induced hypercalcaemia, Paget's disease, bone metastases, osteoporosis. It is more potent than other bisphosphonate in inhibiting induced hypercalcaemia and bone resorption. Adverse events associated with the use of Ibandronate in the management of hypercalcaemia of malignancy was few .They included increasing body temperature, hypocalcaemia and hypophosphataemia. Less commonly, flu - like symptoms and gastrointestinal intolerance may occur.
出处
《中国医药导刊》
2001年第4期275-277,共3页
Chinese Journal of Medicinal Guide
