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抑癌基因PTEN的突变失活在肿瘤发生发展中的作用 被引量：5

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摘要 PTEN是 1997年发现的新的抑癌基因 ,具有双重特异性磷酸酶活性 ,故可通过磷酸化与去磷酸化的动态变化调节正常细胞的生长。PTEN基因的丢失可能会导致PIP3 通路不正常激活 ,从而使细胞无节制的生长。本文从PTEN的发现、结构、作用底物。
作者 赵春艳 曲杰 张耀铮
机构地区 大连医科大学临床生化教研室 大连医科大学附二院检验科
出处 《国外医学（临床生物化学与检验学分册）》 2001年第5期243-245,共3页 Foreign Medical Sciences(section of Clinical Biochemistry and Laboratory Medicine
关键词 PTEN 抑癌基因 信号转导 基因缺失 肿瘤
分类号 R730.2 [医药卫生—肿瘤]
  • 相关文献

参考文献15

  • 1Li J, Yen C, Liaw D, et al. PETN, a putative protein tyroyine phosphatase gene mutated in human brain, breast and prostate cancer[J]. Science, 1997,295 : 1943～ 1947.
  • 2Steck PA, Pershonse MA, Jzsser SA, et al. Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers[J]. Nat Genet, 1997,15 (4): 356～362.
  • 3LI DM, Sun H. TEP1, encoded by a candidate tumor suppressor locus, is a novel protein tryrosine phosphatase regulated by transforming growth factor 3 [J]. Cancer Res,1997,56: 2124～2129.
  • 4Myers MP, Stolarov JP, Eng C. PTEN, the tumor suppressor from human chromosome 10q23,is a dual-specificity phosphatase[J]. Proc Natl Acad Sci USA, 1997,94: 9052～9057.
  • 5Meahama T, Dixon JE. The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger,phosphatidylinositol 3,4,5,-trisphosphate[J]. J Boil Chem,1998,273:13375～13378.
  • 6Cheney IW, Johnson DE, Vaillancourt MT. Suppression of tumoringenicity of glioblastoma cells by adenovirus-mediated MMAC1/PTEN gene transfer[J]. Cancer Res, 1998,58:2331～2334.
  • 7Cheney IW, Neuteboom STC, Vaillancourt MT, et al. Adenovirus-mediated gene transfer of MMAC1/PTEN to glioblastoma cell inhibits S phase entry by the recruitment of p27Kipl into cyclin E/COK2 complexes[J]. Cancer Res,1999,59 (10): 2318～2323.
  • 8Lu Y, Lin YZ, LaPushin R, et al. The PTEN/MMAC1/TEP tumor suppressor gene decreases cell growth and induces apoptosis and anoikis in breast cancer cells[J]. Oncogene, 1999, 18 (50): 7034～7045.
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同被引文献15

  • 1吕霞,孔令非,齐绍文,刘正国,陈小凯.脉络膜黑色素瘤中survivin的表达及其与微血管密度的关系[J].眼科新进展,2006,26(10):755-758. 被引量：9
  • 2朱如玮,刘振延.新型抑癌基因 p16[J].肿瘤,1997,17(3):178-179. 被引量：12
  • 3OKAMOTO A,DEMETRICK DJ,SPILLARE E A,et al. Mutations and altered expression of P16(INK4) in human cancer[J]. Proc Natl Acad Sci USA, 1994,81:11045.
  • 4LI J,YEN C,LIAW D, et al.PTEN,a putative protein tyrosine phosphatase gene mutated in human brain,breast, and prostate cancer[J]. Science, 1997, 275:1943.
  • 5DEPWSKI P L,ROSENTHAL S I,ROES J S. Loss of expterssion of the PTEN gene protein product is associated with poor outcome in breast cancer[J]. Mod Pathol, 2001,14:672.
  • 6Salvesen HB,Stefansson I,Kalvenes MB,Das S,Akslen LA.Loss of PTEN expression is associated with metastatic disease in patients with endometrial carcinoma[J].Cancer 2002;94:2185-2191.
  • 7Han SY,Kato H,Kato S,Suzukj T,Shibafa H,Ishii S,et al.Fuctional evaluation of PTEN missense mutations using in vitro phosphoinositide phosphutase assay[J].Cancer Res 2000;60(12):3147-3151.
  • 8Chung MJ,Jung SH,Lee BJ et al.Inactivation of the PTEN gene protein product is associated with the invasiveness and metastasis,but not angiogenesis of breast cancer.Pathol Int,2004,54 (1):10.
  • 9Hofseth LJ,Hussain SP,Harris CC.p53:25 years after its discovery.Trends Pharmacol Sci,2004,25(4):177.
  • 10Balint EE,Vousden KH.Activation and activities of the p53 tumor suppressor protein.Br Cancer,2001,85(12):1813.

引证文献5

二级引证文献20

国外医学（临床生物化学与检验学分册）
2001年 第5期

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