摘要
目的 研究丙泊酚预期血药浓度、效应室浓度用于判断镇静深度的可行性。方法 选择ASAⅠ～Ⅱ级的择期手术患者 12例 ,以 0 5～ 1mg/L的预期血药浓度梯度 ,逐步上下调整靶控预期血药浓度给予术中镇静 ,每一预期浓度维持 12分钟。双盲记录预期浓度、血液动力学、BIS并计算各指标与镇静评分的相关性、预期浓度、血液动力学与BIS的相关性。结果 预期血药浓度和效应室浓度与BIS的相关系数分别为 - 0 414和 - 0 470 (P <0 0 0 1)。收缩压、预期血药浓度、效应室浓度和BIS指标与镇静深度相关性好 ,r分别为 0 2 6 1、- 0 6 43、- 0 72 2、0 5 35 (P <0 0 0 1)。结论 预期血药浓度、效应室浓度、血压和BIS等指标均可用于预测镇静深度 ,其中效应室浓度预测价值最大。
Objective To study the feasibility of application of target propofol plasma concentrations,effect siteconcentrations,hemodynamic,bispectral index (BIS) to predict sedation level.Methods Twelve ASA physical status of Ⅰ Ⅱ patients were anesthetized with target plasma concentration infusion of propofol,which increased in an increment of 0 5 1mg/L.After loss of consciousness,the propofol infusion rate was decreased in an increment of 0 5 1mg/L until the recovery of consciousness.Each target concentration was lasted for 12min.This was repeated until patients 'crossed over'from unconsciousness to consciousness several times.The electroencephalogram was monitored continuously.Measurements of blood pressure and heart rate were recorded just before and at 3min after each stimulation during induction and awakening.The relationship between target concentration and response to a verbal command,as well as that between response and BIS and hemodynamics,was determined.Results The propofol target concentration and effect site concetration correlated with BIS negatively ( r= -0 414,-0 470)( P< 0 001).Sedation level correlated with systolic blood pressure,target propofol plasma concentration,effect site concentration,and BIS except for heart rate.Conclusions Target propofol concentration,effect site concentration,blood pressure,and BIS could be used to predict sedation level.Effect site concentration would be better to predict the depth of sedation than the other indicators.
出处
《临床麻醉学杂志》
CAS
CSCD
2002年第1期23-25,共3页
Journal of Clinical Anesthesiology
关键词
静脉麻醉药
丙泊酚
镇静深度
双频指数
血药浓度
Intravenous anesthetics
Propofol
Sedation
Bispectral index
Plasma drug concentration
