摘要
目的 研究动静脉瘘、动静脉畸形的组织病理学特征。方法 共包括 16只成年兔及 3例动静脉畸形病例。 16只兔中 14只为实验动物 ,包括A组 9只 ,B组 5只 ;余 2只作为空白对照。实验动物均形成颈部动静脉瘘 ,观察瘘形成后 1～ 3个月及瘘结扎后 1～ 3个月时瘘动静脉病理学变化。此外 ,尚对 3例动静脉畸形病例的动静脉标本作病理学研究。结果 动静脉瘘形成后 ,动脉弹力膜进行性破坏 ,而静脉胶原纤维增生 ,动静脉平滑肌均破坏且排列紊乱 ;瘘结扎后 ,动静脉弹力组织恢复不明显 ,而胶原纤维增生显著。动静脉畸形主要病理表现为胶原纤维的显著性增生和退变。结论 动静脉瘘形成后 ,弹力组织破坏持续加重 ,胶原纤维则修复性增生 ,使动静脉失去原有的弹性。瘘结扎后 ,胶原纤维增生较明显 ,但弹力组织未见恢复。
Objective To investigate the histopathological features of AVFs and AVMs.Methods The histopathological aspects of 14 experimental AVFs in rabbits and three human AVMs were investigated.Of the 14 rabbits with experimental AVFs,9 were from Group A and the other five from Group B.The pathological aspects of deformed vessels from 3 human AVMs were studied.Results In the afferent arteries of patent fistulas,tears of the elastic laminae were constantly present.In the draining veins,proliferation of collagen fibres was prominent,Additionally,the smooth muscle cells exhibited dearrangement both in arteries and veins.All these were progressively aggravated with time.After ligation,the collagen fibres showed further proliferation in the arteries and veins,whereas the elastic tissues were not evidently repaired.The vessels of human AVMs had similar pathological features,except for further proliferation and degeneration of collagen fibres.Conclusion After construction of AVFs,the fistulous vessels exhibite progressive destruction of elastic tissues,reparative proliferation of collagen fibres and dearrangement of smooth muscle cells.Therefore,the elasticity of the vessels is decreased.After occlusion,proliferation of collagen fibres would be accelerated,whereas the elastic tissues would not be evidently repaired.
出处
《现代口腔医学杂志》
CAS
CSCD
2002年第1期17-20,共4页
Journal of Modern Stomatology
