摘要
目的 :评价国产吗氯贝胺的抗抑郁疗效和不良反应。方法 :用国产吗氯贝胺 (MCL)和阿米替林 (AML)进行随机双盲双模拟对照观察 5 0例 ,MCL开放观察 15例。采用汉密顿抑郁量表 (HAMD)、汉密顿焦虑量表 (HAMA) ,副反应量表 (TESS)、临床总体印象量表 (CGI)评定疗效和不良反应 ,并定期检查肝、肾功能、心电图、脑电图、血生化 (Glu、K、Na、Cl)、血压等。结果 :经 8周观察 ,发现MCL抗抑郁疗效与AML相当 ,三组显效率分别为 76 %、80 %、80 % (P >0 .0 5 )。不良反应MCL明显较AML为少 (P <0 .0 1) ,且对血压和肝肾功能等也无明显影响。结论
Objectives:To study the efficacy and side effects of MCL on treating depression.Methods:50 depressive patients divided randomly into MCL and AML groups and 15 cases of MCL group adapted open observation.We measured the efficacy and side effect with HAMD,HAMA,TESS,CGI and tested kidney function,liver function,EET,ECT,biochemical analysis and so on.Results:The efficacy had no difference between MCL and AML by 8\|week observation.The effective rate of three groups were separately 76%,80%,80%( P >0.05)The side\|effects of MCL group was lower than that of AML group ( P <0.01).MCL had no change on kidney function and blood pressure.Conclusion:The study proved that MCL was a effective antidepressant.
出处
《中国民政医学杂志》
2001年第4期207-210,共4页
Medical Journal of Chinese Civil Administration
