摘要
根据磷酸钙骨水泥 ( CPBCs)的基本性能选择符合临床适用的类型 ,并观察适用类型 CPBC固化体超微结构。制备五种 CPBCs粉末 ,即磷酸八钙 -沉淀性羟基磷灰石 ( OCP- PHA)、磷酸八钙 -羟基磷灰石 ( OCP- HA )、磷酸八钙 ( OCP)、缺钙性羟基磷灰石 ( CDHA)、羟基磷灰石 ( HA )。调和液为去离子水和 0 .2 5 M Na2 HPO4 /Na H2 PO4 等摩尔浓度缓冲液。采用 Gillmore双针法测定凝结时间 ,采用 TS- 14单颗粒压缩强度自动测量仪 - 测定压缩强度 ,按照 Ginebra临床应用标准选择适用类型 ,并用扫描电镜观察适用类型 CPBC固化体浸泡仿生液体前后的超微结构。结果表明 :5种 CPBCs中以 OCP- PHA型和 CDHA型 CPBCs的凝结时间和压缩强度符合 Ginebra临床应用标准。 SEM观察两种 CPBCs固化体为多孔结构 ,并随浸泡仿生液体中时间的延长而溶解或溶合。 OCP- PHA型和CDHA型 CPBCs适合于非承重骨的修复 ,其固化体为多孔结构 。
According to the primary properties of calcium phosphate bone cement (CPBCs), we have chosen certain types of them for use in cranioplasty and have observed the microstructure of their set bodies by means of SEM. Five kinds of CPBCs powder have been prepared, including: octacalcium phosphate precipitated hydroxyapatite (OCP-PHA) type, octacalcium phosphate hydroxyapatite (OCP-HA) type, octacalcium phosphate (OCP) type, calcium deficient hydroxyapatite (CDHA) type and hydroxyapatite (HA) type. The mixing liquids were deionized water and 0.25M Na2HPO4/NaH2PO4 buffer solution. The setting time was measured by Gillmore method. The compressive strengths were measured using the TS-14 automatically measured instrument-I of single granule's compressive strength. The CPBC types used for clinical cranioplasty were defined according to Ginebra's Criteria of the CPBCs, and the ultrastructure of the set-bodies of the defined CPBC type was observed by SEM before and after its immersion in Ringer's Solution. Results Two out of five CPBCs, OCP-PHA-CPBC and CDHA-CPBC were selected for clinical cranioplasty. Before and after they were immersed in Ringer's Sol., the SEM found their set-bodies to be structurally porous and to dissolve with the increase of immension time. These data indicate that OCP-PHA-CPBC and CDHA-CPBC are sufficient for the reconstruction of non-stress-bearing bone, and the porous structure of their set-bodies is advantageous to fibroplasty or fibrovasualization in their set bodies.
出处
《生物医学工程学杂志》
EI
CAS
CSCD
2001年第4期568-572,共5页
Journal of Biomedical Engineering
关键词
磷酸钙骨水泥
基本性能
微结构
CPBCs
Calcium phosphate bone cement (CPBC) Primary property Microstructure
