摘要
60羽 42～ 44日龄AA健康肉鸡随机分为对照组A (n=30 ) ,试验组B、C、D (n =30 )。B、C、D则分别为静脉注射 10mg·kg-1Nω 硝基左旋精氨酸甲酯 (L NAME)后 1,2和 4h的 3个组。用右心导管测定肺动脉压 ,同时进行心电描记。然后 ,通过右心导管注入硝普钠 (SNP) ,再次观察并记录肺动脉压 (PAP)及心电图 (ECG)的变化。结果表明 ,(1)静脉注射L NAME后B、C组肉鸡的平均肺动脉压 (mPAP)显著升高 (P <0 0 5 ) ;Ⅱ导联和aVF 导联S波、RS波的波幅增加。Ⅱ导联S波、RS波的波幅与mPAP的相关系数在B和C组分别为 - 0 848,- 0 5 5 3和 - 0 798,- 0 5 12。aVF 导联S波、RS波的波幅与mPAP的相关系数在B和C组分别为 - 0 735 ,- 0 5 96和 - 0 6 6 3 ,- 0 72 4。通过右心导管注入SNP能极显著降低mPAP (P<0 0 1) ,Ⅱ导联S波、RS波的波幅在B和C组的下降幅度较A组显著。Ⅱ导联S波、RS波的波幅变化与mPAP的相关系数B和C组分别为 - 0 895 ,- 0 5 42和 - 0 6 36 ,- 0 6 76。 (2 )D组mPAP ,Ⅱ导联和aVF 导联S波、RS波的波幅与A组差异不显著。
Sixty broilers at aged 42 to 44 days were divided into control group A(n=30)and treatment groups B,C,D(n=30)which were intravenously infused with L NAME,SNP in 1 h, 2 h,4 h respectively.Values of mean pulmonary arterial pressure(mPAP)and electrocardiogram(ECG)were measured.The results showed that:(1)The mPAP was significantly increased(P<0 05)in group B and group C after intravenous infusion of L NAME.S wave,RS wave amplitudes in lead Ⅱ and aV F were deeper in group B and group C than in group A.The correlation coefficient between the mPAP and ECG S wave,RS wave amplitudes for lead Ⅱ were -0 848,-0 553 in group B,and -0 798,-0 512 in group C,while in lead aV F were -0 735,-0 596,-0 663, -0 724 respectively.The mPAP was significantly reduced(P<0 01)in group B and group C after intravenous infusion of SNP.S wave,RS wave amplitudes in lead Ⅱ were reduced in group B and C than in group A.The correlation coefficient between S wave,RS wave amplitudes in lead Ⅱ and mPAP were -0 895,-0 542,-0 636,-0 676 in group B and C respectively.(2)mPAP,S wave,RS wave amplitudes in lead Ⅱ and aV F were not significantly different between group D and group A.It appears likely from these results that the pulmonary vascular endothelium releases NO that in turn reduces the pulmonary vascular resistance or attenuates myocardial contractility in broiler chickens.
出处
《南京农业大学学报》
CAS
CSCD
北大核心
2001年第3期73-76,共4页
Journal of Nanjing Agricultural University
基金
国家自然科学基金 (39970 5 6 8)
高校博士点基金 (B980 0 0 2 )
江苏省九五农业攻关 (BE96 488)资助项目
关键词
肉鸡
平均肺动脉压
心电图
一氧化氮
mean pulmonary arterial pressure
broiler chickens
electrocardiogram
nitric oxide(NO)
