摘要
目的 探讨局灶性脑缺血失联络区乙酰胆碱酯酶 (AChE)、酸性磷酸酶 (ACP)、琥珀酸脱氢酶 (SDH)酶活性的变化。方法 通过脑血流放射自显影和大鼠大脑中动脉栓塞 (MCAO)模型确定失联络区 ,用酶组织化学染色法研究AChE、ACP、SDH的活性变化。结果 局灶性脑缺血后失联络区AChE、ACP活性无明显改变 ,SDH活性下降。结论 局灶性脑缺血失联络区胆碱能神经及溶酶体功能无改变 。
Objective To study the changes in activities of acetylcholineesterase(AChE)?acid phosphatase(ACP) and succinic dehydrogenase(SDH) in diaschisis areas after focal cerebral ischemia. Methods The activities of AChE?ACP and SDH in diaschisis areas which were defined by cerebral blood flow autoradiography in a rat model of right middle cerebral artery occlusion(MCAO) were observed using enzymatic histochemistry. Results With focal cerebral ischemia, there were no changes in AChE and ACP activities in the diaschisis areas, but SDH activity decreased. Conclusion In the diaschisis areas the function of cholinergic system and lysosome was not affected, but metabolic activity of mitochondria decreased.
出处
《中华核医学杂志》
CAS
CSCD
北大核心
2001年第5期273-274,共2页
Chinese Journal of Nuclear Medicine
基金
辽宁省社会发展基金资助项目 (992 2 50 0 1 )
关键词
脑缺血
乙酰胆碱酯酶
酸性磷酸酶
琥珀酸脱氢酶
Cerebral ischemia
Acetylcholinesterase
Acid phosphatase
Succinate dehydrogenase
