摘要
目的:评价连续服用国产低剂量复方18-甲基炔诺酮(复方18-甲)对妇女脂质代谢的影响。方法:对150例连续服用国产低剂量复方18-甲5～25年健康妇女的血清中TG、TC、HDL-C、LDL-C、ApoA1、ApoB、Lp(a)含量用生化法进行测定,同期使用宫内节育器(IUD)的131例妇女作为对照。两组妇女年龄、使用措施时间、体重指数、经济收入等均无显著差异。结果:与对照组比较,服用国产低剂量复方18-甲5～25年妇女血清各项脂质水平均有不同程度的升高,TG、HDL-C和Lp(a)均值显著升高(P<0.05);ApoA1均值极显著升高(P<0.01)。服药时间<15年时,各项脂质水平高于对照组但未达到显著差异;服药时间≥15年时,TG、ApoA1和Lp(a)显著高于对照组,其它指标也高于对照组但无显著差异。结论:复方18-甲对脂代谢有多重影响。复方18-甲在其连续服用15年内因其对TC和LDL-C作用强于HDL-C,尤其服药时间≥15年时,其对血清Lp(a)的显著增高作用提示长期服用国产低剂量复方18-甲可能对心脑血管系统有不利影响。
To assess the effect of long-term use of low-dose combined 18-methyl-Norethisterone (Norgestrel)on lipid metabolism. Serum TG,TC,HDL-C,LDL-C, ApoA1, ApoB and Lp(a) were assayed in 281 health women using contraceptive methods for 5-25 years grouped as Norgestrel and control (IUD). The two groups were similar in age,body mass index(BMI) ,continued period of contraceptives use and income. The results showed that changes of varying degree of lipid and lipoprotein parameters were increased in Norgestrel-group compared with control. TG,HDL-C, ApoA1 were significantly increased simultaneously(P<0. 05)and a highly significant increase(P<0. 01)in Lp(a),an independent risk factor for cardiovascular disease,was found in Norgestrel group. Lipid parameters in Norgestril use less than 15 years were higher than those in control but there was no significant difference. TG, ApoAl and Lp(a)were significantly increased in Norgestrel use more than 15 years and other lipid parameters were higher but there was no significant difference compared with control. Norgestrel has multiple effects on lipid lipoprotein parameters. Increasing effect on TC and LDL-C was stronger than that on HDL-C in Norgestrel use less than 15 years, particularly Lp(a) was increased significantly in Norgestrel use more than 15 years. It is suggested that there was potential harmful effect of norgestrel on the cardiovascular system.
出处
《中国计划生育学杂志》
2001年第4期219-220,222,共3页
Chinese Journal of Family Planning
关键词
低剂量
复方口服避孕药
脂代谢
Low dose Combined contraceptive pill Lipid metabolism
