摘要
目的 探讨重症肝炎患者血清甲状腺激素的变化情况及其临床意义。方法 采用放射免疫法检测 32例重症肝炎患者、15例慢性肝炎患者及 14例正常对照的血清总三碘甲状腺原氨酸 (TT3)、总甲状腺素 (TT4)及促甲状腺激素(TSH)水平 ,比较各组之间的差异。结果 重症肝炎患者血清TT3、TT4水平均明显低于正常对照组 (P <0 .0 5 ) ,其中死亡组的TT3及TT4水平明显低于存活组 (P <0 .0 5 ) ,而存活组患者危重期的TT3水平明显低于恢复期 (P <0 .0 1) ,各组血清TSH值无明显差异。重症肝炎患者血清总胆红素 (TB)与TT3水平呈负相关。结论 重症肝炎患者存在血清甲状腺激素的异常代谢 ,其严重程度对判断患者的预后可能有一定的作用。
Objective To study the change and its clinic significance of serum thyroid hormone levels in the patients with severe hepatitis.Methods Serum levels of TT 3,TT 4 and TSH were detected in 32 patients with severe hepatitis,15 patients with chronic hepatitis and 14 normal controls by radioimmunoassay(RIA).Results Serum TT 3 and TT 4 levels were significantly lower in patients with severe hepatitis than in normal controls,and were significantly lower in the died patients than in alive.Levels of TT 3 were significantly lower at the dangerous stage than that of convalescence stage.There was no difference of TSH levels in all groups above.There was a negative correlation between serum total bilirubin and TT 3 level in these patients.Conclusion There were abnormal metabolisms of thyroid hormones in severe hepatitis patients,the chang extent of thyroid hormones might aid to evaluate the severity of the illness and to estimate the outcome of the patients.
出处
《铁道医学》
2001年第5期301-303,共3页
Railway Medical Journal
关键词
重症肝炎
甲状腺激素
总胆红素
severe hepatitis
thyroid hormone
tolal bilirubin
