摘要
目的 测定 Graves病 (GD)患者血清肿瘤坏死因子(TNF- α)、白细胞介素 1(IL- 1)、白细胞介素 2 (IL- 2 )、白细胞介素 6 (IL - 6 )的水平及在抗甲状腺药物治疗过程中的变化 .方法 32例 GD患者在确诊时、治疗约 6周和 6月时用放射免疫法测定血清 TNF- α,IL- 1,IL- 2 ,IL- 6 ,TSH,TT3,TT4的水平 . 2 5例年龄与性别相匹配的健康志愿者作为正常对照 .结果 1与正常对照组相比 ,TNF- α在缓解前明显降低 (1.0 1± 0 .18)μg· L- 1 (P<0 .0 0 1) ,缓解中开始升高(1.2 7± 0 .19)μg· L- 1 ,缓解后继续升高 (1.42± 0 .17)μg·L- 1 ,但仍低于正常对照组 (1.6 9± 0 .15 ) μg· L- 1 ;IL- 1,IL-6在缓解前明显升高 (0 .39± 0 .0 9)μg· L- 1 ,(1.79± 0 .2 1)μg· L- 1 (P<0 .0 1) ,缓解中即降低 (0 .2 8± 0 .0 7) μg· L- 1 ,(1.5 1± 0 .19) μg· L- 1 ,缓解后 (0 . 2 1± 0 . 0 7) μg· L- 1 ,(1.40± 0 .2 1)μg· L- 1 与正常对照组 (0 .2 0± 0 .0 6 )μg· L- 1 ,(1.41± 0 .16 )μg· L- 1 无显著差异 ;IL - 2在缓解前明显降低(4 .2± 1.2 ) μg· L- 1 (P<0 .0 1) ,缓解中即升高 (5 .0± 1.7)μg· L - 1 ,缓解后 (6 .1± 2 .7) μg· L- 1与正常对照组 (6 .3± 2 .3)μg· L- 1无显著?
AIM To investigate the serum levels of tumor necrosi s factor alpha (TNF-α), interleukin 1 (IL-1), interleukin 2 (IL-2) and inter leukin 6 (IL-6) and to determine how the levels would be affected by treatment with antithyroidism drugs (ATD). METHODS Serum TNF-α, IL-1, IL-2, IL-6, TSH, TT 3 and TT 4 levels of 32 Graves diseases patients (12 male and 20 female , aged 34.1±9.8 years) at the time of diagnosis and after 6 weeks and 6 mont hs of treatment were measured. 25 age- and sex-matched healthy subjects se rved as controls. TNF-α, IL-1,IL-2, IL-6, TSH, TT 3 and TT 4 levels were measured by immunoradiometric assay. RESULTS TNF-α levels before the tr eatment (1.01±0.18)μg·L -1 were lower than those after 6 weeks of t reatment (1.27±0.19)μg·L -1 and 6 months of treatment(1.42±0.17)μg·L -1, and those in the controls (1.69±0.15) μg·L -1(P<0.001). IL-1, IL-6 levels before the treatment (0.39±0.09)μg·L -1, (1.79±0.21)μg·L -1 were high er than those after 6 weeks of treatment (0.28±0.07)μg·L -1, (1.51±0 .19)μg·L -1 and 6 months of treatment (0.21± 0.07)μg·L - 1,(1.40±0.21)μg·L -1, and those in the controls(0.20±0.06)μg·L -1, (1.41±0.16)μg·L -1 (P< 0.01 for all). But IL-1, IL-6 levels after 6 months of treatment and in controls showed no statis tic differen (P>0.05 for all). IL-2 levels before the treatment (4.23±1.19)μg·L -1 were lower than those after 6 weeks of treatment (5.0±1.7)μg·L -1 and 6 months of treatment (6.1±2.7)μg·L -1 in controls(6.3±2.3)μg·L -1 (P<0.01). No statistic difference was defected befween the IL-2 levels after 6 weeks and 6 months of treatmeat and those in the controls (6.3±2.3) μg·L -1 ( P>0.05). There was a negative correlation between TNF-α, IL-2 levels and TT 3, TT 4 levels(P<0.05 for all). There was a positive correlation between IL-1, IL-6 levels and TT 3, TT 4 levels (P<0.05 for all). CONCLUSION In graves disease the serum cytokines levels might reflect the immune activity and be implicated in immunopathology and prognosis.
出处
《第四军医大学学报》
北大核心
2001年第18期1710-1713,共4页
Journal of the Fourth Military Medical University
