摘要
目的 评价短暂性脑缺血发作 (TIA)是否有脑保护作用 .方法 选择 1994/ 1999既往有同侧 TIA的脑梗塞患者6 8(男 47,女 2 1)例 ,平均年龄 (6 1± 11)岁 ,并按 1∶ 1配对选择无 TIA病史的脑梗塞患者进行病例对照观察 ,采用加拿大神经缺损评分量表 (CNS) ,比较两组患者入院时及 3mo后的神经功能状态积分 .结果 两组患者的年龄及其他血管病危险因素如 :高血压病、糖尿病、高胆固醇血症、冠心病及吸烟史等均无显著性差异 ;入院时及 3mo后 ,梗塞前有 TIA的患者其神经功能积分为 7.2 5 6± 0 .734及 9.0 0 8± 0 .46 0 ,与对照组相比均有显著性差异 (P=0 .0 19及 P=0 .0 0 2 ) .结论 缺血耐受在梗塞前有
AIM To evaluate the effect of ischemic tolerance in patients with ipsilateral TIA before cerebral infarction (CI). METHODS First ever CI patients ( n =68) admitted to our hospital between July 1994 and July 1999 with prior TIA (47 men, 21 women; mean age, 61±11 years) were enrolled. For each patient with ipsilateral TIA before CI, we selected 1 age and sex matched CI patient without prior TIA.A case control study was conducted. RESULTS There were no significant differences in baseline characteristics, such as age, hypertention, diabetes mellitus, hypercholesterolemia, coronary heart disease and smoking. According to Candian Neurological Scale score, patients with prior TIA had a milder neurologic deficits than those without prior TIA at admission (7.256±0.734 and 6.872±1.112 respectively, P =0.019) and 3 months later (9.008±0.460 and 8.602± 0.932, P =0.002). CONCLUSION A TIA may allow the brain to develop endogenous protective mechanisms against a subsequent ipsilateral CI. Ischemic tolerance might occur in the human brain.
出处
《第四军医大学学报》
北大核心
2001年第22期2094-2097,共4页
Journal of the Fourth Military Medical University
关键词
脑缺血
缺血预处理
耐受性
cerebral ischemia
ischemic preconditioning
