摘要
目的 探讨雌激素 (E)、褪黑素 (MT)缺乏对大鼠学习记忆及海马胆碱能纤维密度的影响。方法 用Y型迷宫测试淘汰学习记忆障碍大鼠 ,将学习正常大鼠分为正常、假去卵巢 (假OVX)、OVX、假去松果体 (假PX)、PX、假OVX +假PX、OVX +PX 7组。 90d后再行Y型迷宫测试 ,乙酰胆碱酯酶 (AChE)组织化学检测海马CA1 4区AChE。结果 大鼠学习记忆能力及AchE阳性纤维密度在正常、假手术各组间无显著差别 ,在OVX、PX、OVX +PX组间依次显著降低 ,三组均比正常及假手术各组显著降低。结论 OVX、PX可使大鼠学习记忆及海马胆碱能纤维密度降低。PX作用大于OVX ,联合作用大于单独作用。
Objective To investigate the effects of decreased estrogen?melatonin on learing and memory abilities and density of cholinergic fibers in the hippocampus.Methods After testd by Y type maze,the rats with normal study ability were randomly divided into Normal,Sham ovariotomy, ovariotomy, Sham pinealectomy, pinealectomy, Sham ovariotomy + Sham pinealectomy, ovariotomy + pinealectomy seven groups.After 90d, to test learing and memory abilities oncd again,to study the changing of acetycholinesterase (AChE) histochemistry of the hippocampus CA1 4 areas.Results Learing and memory abilities and the AChE positive fibers density had no significant distinction among Normal ?All sham operated groups,but being significantly gradually decreased in OVX?PX?OVX +PX groups, and OVX+PX group < PX group < OVX group < Normal and Sham operated groups.Conclusion OVX?PX resulted in disorder of learing and memory abilities and reduction of AChE positive fibers density of the hippocampus CA1 4 areas.,and OVX+PXgroup< PXgroup< OVXgroup.
出处
《中国行为医学科学》
CSCD
2001年第6期535-536,541,共3页
Chinese Journal of Behavioral Medical Science
