摘要
目的 研究多梗塞性痴呆 (MID)患者脑脊液 (CSF)中神经元特异性烯醇化酶 (NSE)的变化及其临床意义。方法 采用双抗体夹心ELISA法对 55例MID患者CSF中NSE浓度进行测定 ,另选 72例脑梗塞 (CI)患者及 3 2例正常人作为对照。患者的智能水平采用简易智能量表 (MMSE)测定 ,并参考DSM Ⅳ诊断标准及Hachinski缺血评分。结果 MID急性发作组及CI急性期组CSF中NSE浓度明显高于对照组 (P <0 .0 1 ) ;MID稳定期组CSF中NSE浓度低于对照组 (P <0 .0 5) ;CI恢复期组CSF中NSE的浓度与对照组无显著差异。CSF中NSE的浓度与MMSE评分无显著相关 (r =-0 .0 2 2 57,P >0 .0 5)。结论 并非所有MID患者CSF中NSE呈一致性变化。CSF中NSE的含量变化可反映MID患者的脑组织功能状态。但是NSE并不是一种智能因子 ,并不能直接反映MID患者的智能状态。
Objective To study the change of neuron specific enolase (NSE) in cerebrospinal fluid(CSF) and its clinical significance in patients with multi infarct dementia(MID).Methods The concentration of NSE in CSF was determined in 55 patients with MID by means of ELISA. Seventy two patients with cerebral infarction (CI) and 32 healthy persons were used as controls. Mini mental state examination (MMSE) was used to examine the intellectual level of patients, with DSM IV diagnosis standard and Hachinski Ischemia Score as references.Results NSE concentration in CSF in MID acute episode group and CI acute phase group were significantly higher than that in normal controls respectively(P<0.01). NSE concentration in MID stationary phase group was lower than that in normal controls(P<0.05).No significant difference was found in NSE concentration in CSF between CI recovery phase group and normal controls. There was no significant correlation between NSE concentration in CSF and MMSE scores (r=-0.02257,P>0.05).Conclusion NSE concentration in CSF of all patients with MID did not present concordant changes at all.The change of NSE concentration in CSF can respond the brain functional status in patients with MID. However, NSE can not directly indicate the intellectual status of patients, for it is not a kind of intellectual factor.
出处
《中国行为医学科学》
CSCD
2001年第6期532-534,共3页
Chinese Journal of Behavioral Medical Science
基金
本课题为重庆市科委重点资助项目 (1 999~ 2 0 0 1 )
关键词
多梗塞性痴呆
神经元特异性烯醇化酶
脑脊液
血管性痴呆
Multi infarct dementia
Neuron specific enolase
Cerebrospinal fluid
Mini mental state examination
