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超速起搏预适应保护缺血心肌的实验观察 被引量：3

Observation of the Protective Effect of Superspeedy Pacing Preconditioning on the Ischemia-reperfusive Myocardium
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摘要 目的　探讨超速起搏预适应 (PP)对缺血再灌注心肌梗塞范围及室性心律失常发生率的影响。　方法　 2 4只健康家兔随机分为缺血再灌注损伤组 (IR组 )和超速起搏预适应组 (PP组 ) ;测定两组梗塞区、危险区的心室重量 ,计算梗塞范围 ,并对室性心律失常发生率进行评分。　结果　 (1)心脏 IR组和 PP组梗塞区检测结果 :梗塞区心室重量为 44 1.3± 31.0 3m g比 175 .7± 41.8m g,梗塞范围为 42 .4%± 3.6 %比 16 .7%± 1.2 % ,差异有显著性(P<0 .0 1)。 (2 ) IR组和 PP组室性心律失常发生率评分为 3.6 7± 0 .89比 1.83± 0 .72 ,差异有显著性 (P<0 .0 1)。　结论　 (1) PP降低心肌急性缺血再灌注时梗塞范围 ;(2 ) PP降低心肌急性缺血再灌注时室性心律失常的发生。 Objective\ To investigate the protective effect of the overdriving pacing preconditioning.\ Methods\ 24 rabbits were devided into ischemia\| reperfusion group(IR group) and overdriving pacing preconditioning group(PP group).\ The infarct size(IS), area at risk(AAR) and the appearance of ventricular arrhythmias of the two groups were examined.\ Results\ (1)The weight of infarct size of the two groups were 441 3±31 03 mg vs 175 7±41 8 mg, IS/AAR(%) were 42 4%±3 6% vs 16 7%±1 2%(P<0 01).\ (2)The appearance of ventricular arrhythmias of the two groups were 3 67±0 89 vs 1 83±0 72(P<0 01).\ Conclusion\ (1)PP could alleviate the injury of ischemic myocardium and reduce the myocardial infarct size; (2)PP could reduce the occurence of ventricular arrhythmias.\;
作者 林晓红 吴黎明 王一波
机构地区 福建医科大学附属协和医院急诊科 福建医科大学附属协和医院心内科
出处 《福建医科大学学报》 2001年第3期244-246,249,共4页 Journal of Fujian Medical University
基金 福建省教育厅科研基金资助项目 ( K2 0 0 5 9)
关键词 心肌梗塞 心律失常 心肌再灌注 缺血预处理 心肌 家兔 myocardial infarct arrhythmias myocardial reperfusion ischemic preconditioning,myocardial rabbit
分类号 R540.5 [医药卫生—心血管疾病] R－332 [医药卫生]
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参考文献13

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同被引文献14

  • 1Murry C E, Jennings R B, Reimer K A. Preconditioning with ischemic: a delay of lethal cell injury in ischemic myocardium[J]. Circulation, 1986,74: 1124 -1136.
  • 2Yamashita N, Kuzuyu T, Hsoshida S, et al. Relationship between time interval from preconditioning to sustained ischemia and its effects on limiting infarct size[J]. J Mol Cell Cardiol, 1992,24 (Suppl) :S150.
  • 3Yamashita N, Nishidn M, Hoshida S, et al. Induction of manganese superoxide dismutase in rat cardiac myocytes increases to lerance to hypoxia 24 hours after preconditioning[J]. J Clin Invest, 1994,94 : 2193.
  • 4Jones W K, Flaherty M P, Tang X L,et al. Ischemic preconditioning iNOS transcript levels in conscions rabbits via a nitric oxide - dependent mechanism [J]. J Mol Cell Cardiol, 1999,31 : 1469 - 1481.
  • 5Bolli R,Manchikalapudi S,Tang X L,et al. The protective effect of late preconditioning against myocardial stunning in conscious rabbits is mediated by nitric oxide synthase,evidence that nitric oxide acts both as a trigger and as a mediator of the late phase of ischemic preconditioning [J]. Circ Res, 1997,81 : 1094 - 1107.
  • 6Vegh A,Szekers L,Parratt J R. Transient ischemia induced by rapid cardiac pacing results in myocardial preconditioning [J].Cardiovasc Res,1991,25:1051 -1053.
  • 7Zhou Xiaobo,Zhai Xiaolin, Ashraf M,et al. Direct evidence that initial oxidative stress triggered by preconditioning contributes to second window of protection by endogenous antioxidant enzyme in myocytes[J]. Circulation,1996,93:1177 - 1184.
  • 8Kim S J,Ghaleh B,Kudej R K,et al. Dalayed enhanced nitric oxide- mediated coronary vasodilation following brief ischemia and prolonged reperfusion in conscious dogs [J]. Circ Res, 1997, 81:53-59.
  • 9Jones W K,Flaherty M P,Tang X L,et al. Ischemic preconditioning iNOS transcript levels in conscious rabbits via a nitric oxide - dependent mechanism [J]. J Mol Cell Cardiol, 1999,31 :1469 - 1481.
  • 10孙国铨,单绮娴,沈岳良,夏强.外源性腺苷对离体大鼠心肌易颤性的影响[J].浙江医学,2000,22(9):526-528. 被引量：2

引证文献3

二级引证文献5

福建医科大学学报
2001年 第3期

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