摘要
目的 :综合分析和评价临床病理因素对胰腺癌手术预后影响。方法 :对手术切除 4 4例胰腺癌 12个临床病理因素进行单因素和多因素COX模型分析。结果 :单因素分析表明 :肿瘤大小、淋巴结转移、胰周浸润、大血管侵及、肿瘤残留、远隔转移和临床分期与胰腺癌手术预后显著相关 (P<0 .0 5或P <0 .0 1) ;年龄、性别、肿瘤部位、病理组织类型、分化程度与预后无关 (P >0 .0 5 )。应用COX模型对上述筛选出的 7个有显著意义的因素进行多因素分析表明 :淋巴结转移和肿瘤大小是影响胰腺癌手术预后最显著的两个独立因素。结论
Objective: Our purpose was to evaluate the influence of various clinicopathologic factors on the survival of patients with pancreatic carcinoma. Methods: A computer analysis was performed on 44 patients who underwent resection for pancreatic carcinoma. Results: Univariate analysis identified 7 factors that were associated with a significant outcome: size of the tumor(P<0.05),lymph node metastasis (P<0.01), peripancreatic invasion (P<0.01), major vessel involvement (P<0.05), residual tumor (P<0. 01), distant metastasis (P<0.05) and clinical stage(P<0. 01). However, when the interactive effects of these factors were taken into account,the lymph node metastasis and size of the tumor were selected as the two most significant prognostic factors in a multivariate analysis by using the Cox proportional hazard regression model. The age, sex, location of primary lesion,histologic type of lesion, and grade of differentiation were not significantly associated with prognosis. Conclusion: These results can help clinical practice on evaluating postoperative prognosis and selecting reasonable surgery therapy
出处
《中国医科大学学报》
CAS
CSCD
北大核心
2001年第6期459-460,462,共3页
Journal of China Medical University
关键词
胰腺癌
临床病理学
预后
COX模型
pancreatic carcinoma
clinicopathology
prognosis
Cox proportional hazard regression model
