摘要
目的:探讨抗菌药物产生药物热的一般规律。方法:收集本院1998年6月～1999年9月间住院患者抗感染治疗中出现的持续高热,经临床证实为药物热的12例患者进行讨论分析。结果:12例患者分别对氧哌嗪青霉素等抗菌药物产生了药物热,其中6例对多种抗菌药产生药物热。9例经停用抗生素,体温于停药后的第2～3天降至正常,3例经改用乳酸环丙沙星后,则体温迅速下降。结论:β内酰胺类抗生素如氧哌嗪青霉素产生药物热较多见。有时较难鉴别易误诊,故请临床医生加以注意。
Objective: To profile the drug- fever due to antimicrobial agents.Methods: In this study 12 hospitalized cases between June 1998 and September 1999 were enrolled who had drug - fever confirmed during antiinfective treatment. Results: More antimicrobials resulted in fever in 12 patients, even more than one drug responsible for the fever in 6 cases. The temperature was back to normal 2-3 days after withdrawal of the drug (9 cases) while it was down pretty soon with another suitable drug substituted (3 cases) .Conclusion: Drug- fever is mainly caused by β- lactam antibiotics like piperacillin sodium. It is important that doctors should bear the ADR of drug - fever in mind to avoid misdiagnosis.
出处
《药物不良反应杂志》
2001年第3期151-154,共4页
Adverse Drug Reactions Journal
关键词
抗菌药物
药物热
临床分析
drug-fever
antimicrobial agents
clinical analysis.
