摘要
目的 探讨进展期胃癌患者围手术化疗期的细胞免疫功能及手术、化疗、免疫制剂对其影响。方法 第一阶段经手术切除的 41例胃癌患者 ,随机分为 :1.化疗组 ;2 .免化组 (5 -氟脲嘧啶联用干扰素 -alb) ;3 .单纯手术组 (对照组 )。分别于术前、术后 2周、术后 6周、术后 10周进行T细胞亚群NK细胞检测 :第二阶段对经胃癌根治术的 36例患者围手术化疗期进行了 5 -氟脲嘧啶联用干扰素 -alb的临床治疗观察。结果 进展期胃癌患者术前免疫功能存在不同程度的障碍 ,术后短期内无明显改变。结论 术后化疗可损害患者的免疫状况、联用干扰素 (IFN)可减轻化疗对免疫的损伤 (术后 6周以上尤明显 )。
Objective To investigate the cell-mediated immune function in patients with gastric carcinoma during perioperative chemotherapy. Method 41 patients were assessed with NK cell and level of T lymphocyte 2 weeks before and 2 and 6 weeks after operation, and after treatment of 5-FU and INF-alb in 36 gastrectomy patients. Results and Conclusion 1. patients with evolved gastric carcinoma had different impairment of immune function before operation, and impairment was not significantly changed after operation, 2. the immune function could be impaired by chemotherapy, however the application of INF could lighten the impairment, 3.patients with gastric carcinoma should maintain INF treatment to improve immune function.
出处
《云南医药》
CAS
2001年第5期370-372,共3页
Medicine and Pharmacy of Yunnan
关键词
胃癌
免疫功能
T细胞亚群
Chemotherapy
Gastric carcinoma
Immune function
