摘要
目的研究低聚魔芋葡甘聚糖醛酸丙酯硫酸酯钠盐的抗凝和抗栓作用。方法应用玻片法研究对小鼠凝血时间的影响 ;应用大鼠体外颈动脉 颈静脉血流动旁路法形成血小板血栓模型 ,研究其对血栓形成的影响 ;并对兔凝血活酶时间 (PT)和纤维蛋白原 (Fg)的影响进行研究。结果剂量在 0 .9～ 3 .6g kg时 ,能明显延长小鼠的凝血时间 ;在 0 .2 5～ 1.0g kg时 ,有明显抗血栓形成的作用 ;剂量为 0 .2 5～ 0 .75g kg时 ,延长PT作用和降低Fg含量效果显著 ;其LD50 为 8.81g kg。结论该物质具明显的抗凝血和抗血栓作用 。
PurposeThe aim is to study the anticoagulability and antithrombotic activity of the hydroxylpropyl oligo konjac glucomannuronate sulfate.MethodsThe effects on coagulation time of mice were observed by slide method.Its effects on antithrombus formatiion were observed by the thrombus mode, which was formed by carotid artery venous blood bypass method of rats in vitro. Its effects on the prothrombin time(PT) and the fibrinogen content were also studied by reagent boxes.ResultsAt the dose of 0.9～3.6 g/kg,it could prolong the coagulation time of mice significantly; At 0.25～1.0 g/kg, its antithrombotic activity was significant. At the dose of 0.25～0.75 g/kg, its effects on the prothrombin time and the decrease of the fibrinogen content were significant. Its LD 50 was 8.81 g/kg.ConclusionThe product possessed anticoagulability and antithrombotic activity,and it is a promising novel low molecular weight heparinoid substance for angiocardiopathy prevention.
出处
《中国生化药物杂志》
CAS
CSCD
2001年第5期221-223,共3页
Chinese Journal of Biochemical Pharmaceutics
基金
湖北省科技厅重点科技攻关项目 ( 991P14 0 2 7)
关键词
魔芋葡甘聚糖硫酸酯化
抗凝血
抗血栓
低分子类肝素
Konjac glucomannan sulfated
Anticoagulability
Antithromboitc activity
Low molecular weight heparinoid
