摘要
目的 :探讨高血压病和脑卒中患者内源性维生素 C、E的抗氧化作用。方法 :应用紫外分光光度法测定 2 3例高血压病患者、 30例高血压性脑出血患者、 2 5例缺血性脑卒中患者和 2 0例正常对照组的血清维生素 C、E,超氧化物岐化酶 (SOD)和丙二醛 (MDA)的含量。结果 :与正常对照组对比 ,高血压病组 :维生素 C、 E,SOD、 MDA水平无明显改变 ;脑出血、脑缺血组急性期 :维生素 C、E、SOD含量明显降低 (P<0 .0 1) ,MDA水平明显升高(P<0 .0 1) ;恢复期 :维生素 C、 E含量恢复正常 ,SOD含量仍降低 (P<0 .0 5 ) ,MDA仍增高 P<0 .0 5 )。结论 :在脑卒中急性期患者维生素 C、 E水平明显降低 ,但随着病情好转逐渐恢复正常 ,同时伴随 SOD、MDA水平改变。
Objective:To study clinical significance of endogenous vitamin C 、E in patients with hypertension and stroke.Methods:The serum vitamin C、E,Malondialdehyde(MDA),superoxide dismutase(SOD) were determined by ultraviolet spectrophotometry in patients with hypertension(23 cases)、hypertensive cerebral hemorrhage (CH,30 cases)、ischemic cerebrovascular disorders(IC,25 cases) and control groups(20 cases).Results:Compared with control group,at acute stage of stroke,the Vit C、E and SOD levels significantly reduced( P <0 01),the MDA level significantly increased( P <0 01);at convalescent stage,the Vit C、E gradually recover to normal,the SOD still reduced( P <0 05),the MDA still incresed( P <0 05).Conclusion:The endogenous Vit C、E have significant change in patients with acute stage of stroke,it gradually recovers to normal in convalescent stage.Meanwhile the SOD and MDA change accordingly.
出处
《心血管康复医学杂志》
CAS
2001年第1期5-6,共2页
Chinese Journal of Cardiovascular Rehabilitation Medicine
