摘要
目的 :研究大肠癌中 P5 3的表达与浸润转移的关系。方法 :应用 S- P免疫组织化学方法检测大肠癌中 P5 3的表达。结果 :大肠癌中 P5 3的阳性率为 5 1.2 %。大肠癌中 P5 3过表达与浸润程度 (P<0 .0 1)和淋巴结转移 (P<0 .0 5 )有关。结论 :P5 3过表达在大肠癌的浸润转移过程中起着重要作用。
Objective:To study the relations between the colorectal carcinoma invasion or metastasis and the P53 expression.Methods:The expression of P53 was determined by S P immunohistochemistry technique.Results:The frequency of positive P53 expression in colorectal carcinoma was found to be 51.2%,and an over expression of P53 was highly related to the degrees of the corcinoma invasion( P <0.01) and metastasis to lymph nodes ( P <0.05).Conclusion:An over expression of P53 plays an important role in the invasion and metastasis of colorectal carcinoma.
出处
《华夏医学》
2001年第4期432-433,共2页
Acta Medicinae Sinica
关键词
大肠癌
P53癌基因
免疫组织化学
colorectal carcinoma
P53 oncogene
immunohistochemistry
