摘要
目的 探讨急性脑梗死 (ACI)患者血清肿瘤坏死因子 α(TNF α)水平变化及与胰岛素抵抗 (IR)的关系。方法 采用氧化酶法、放免法和酶联免疫法分别测定 3 8例ACI患者 (A组 )、2 5例正常健康人 (B组 )的空腹血糖 (FBG)、空腹胰岛素(FINS)及血清TNF α值 ,并计算胰岛素敏感指数 (ISI)。结果 A组FINS ,TNF α水平较B组显著增高 ,而ISI较B组显著降低。相关分析发现 ,TNF α与ISI呈显著负相关 ,而与FINS呈显著正相关。结论 ACI患者TNF α水平增高 ,且与胰岛素抵抗并存 ,可能参与脑梗死的发生和发展。
Objective To investigate the changes of tumor necrosis factor-α(TNF-α)with acute cerebral infarction(ACI)and the relationship between TNF-α and insulin resistance(IR). Methods 38 patients with ACI(group A); 25 health without cerebral infarction (group B) were selected to compare fasting blood-glucose(FBG), fasting blood-insulin(FINS)and serum TNF-α by oxidase method, RIA and ELISA, Insulin sensitivity index(ISI)was also calculated. Results Analysis of variance revealed that FINS, TNF-α were significantly higher while ISI lower in group A than those in group B. Correlation analysis showed that TNF-α was negatively correlated to ISI, and positively associated TNF-α and FINS. Conclusion The study indicates that significantly hight level of TNF-α and IR play an important role in the development of cerebral infarction.
出处
《临床军医杂志》
CAS
2001年第3期18-19,共2页
Clinical Journal of Medical Officers
关键词
脑梗死
肿瘤坏死因子
胰岛素抵抗
ACI
cerebral infarction
tumor necrosis factor-a
insulin resistance
