摘要
目的 观察 1993～ 2 0 0 0年结核分支杆菌的耐药率流行趋势。方法 采用绝对浓度间接法对 4种药物进行耐药测定。结果 初始耐药率由 1993～ 1994的 34 .6%下降至 1999～ 2 0 0 0年的18.2 % ,链霉素和异烟肼的初始耐药频率由 1993～ 1994年的 2 2 .6%、13.2 %下降至 1999～ 2 0 0 0年的13.4 %、7.8% ;复治耐药率由 1993～ 1994年的 5 2 .1%下降至 1999～ 2 0 0 0年的 35 .7%。MDR的总耐药率 1993～ 1994年为 9.5 % ,1999～ 2 0 0 0年的 7.6%。结论 大连市开展世行贷款项目以来初始及复治耐药率均呈下降趋势 ,但MDR的总耐药率未出现明显下降。
Objective To observe the epidemic trend of drug resistance of the smear positive tuberculosis in 1993～2000.Methods All of the strains of M.tuberculosis from new register smear positive tuberculosis were tested for resistance to INH RFP EMB SM by absolute concentration methods.Results The rate of initial resistance declined from 34.6% in 1993～1994 to 18.2% in 1999～2000.The resistance rate to SM and INH declined from 22.6%,13.2%in 1993～1994 to 13.4%,7.8% in 1999～2000 respectively.The rate of the acquired resistance declined from 52.1% in 1993～1994 to 35.7% in 1999～2000. The total drug resistance rate of MDR was 9.5% in 1993～1994 and 7.6% in 1999～2000.Conclusion The rate of initial and the acquired drug resistance was declined.The total rate of drug resistance of MDR did not decline.
出处
《中国防痨杂志》
CAS
北大核心
2001年第5期291-293,共3页
Chinese Journal of Antituberculosis
