摘要
目的：考察维生素环糊精包合物中维生素D3的稳定性。方法：以正相高效液相色谱法测定维生素D3含量测定，薄层层析法分析分解产物。采用3000 Lx 光照、80 ℃与40 ℃, RH=76%和RH=92.5%条件下放置，考察含量改变。结果：维生素D3在光、热下极不稳定，含量迅速下降，薄层层析明显可见多个分解产物；与维生 素D3比较，D3-β-环糊精(D3-β-CD)包合物的抗热、抗光和抗湿热等稳定性均有 显著提高（P<0.01）。结论：将维生素D3制成D3-β-CD包合物是提高其稳定性的有效方法。
OBJECTIVE To investagate the stability of vitamine D3 in beta-cyclodextrin. METHODS The concentration of vitamine D3 was determined by HPLC,the degradation produc ts were detected with thin-layer chromatography. RESULTS Compared with drug substance D3 in the inclusion was more stable. CONCLUSIONS This is a efficient method to prepare the D3-β-CD for enhancing the stabili ty of vatimine D3.
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
2001年第10期584-586,共3页
Chinese Journal of Hospital Pharmacy
