摘要
目的 比较国产注射用头孢呋辛钠与进口注射用头孢呋辛钠 (对照组 )治疗下呼吸道感染的疗效和安全性。方法 在 3家医院进行前瞻性多中心随机比较 ,共治疗 12 0例患者 ,头孢呋辛钠组和对照组均静脉滴注 ,3g/ d,疗程 7～ 14d,一般资料相似 (P>0 .0 5 )。结果 两组临床疗效无显著性差异 (P>0 .0 5 ) ,痊愈率分别为 91.7%和 95 .0 % ,细菌阳性率为 79.2 % (95 / 12 0 ) ,细菌清除率分别为 95 .2 %和 10 0 .0 % ,两组在统计学上无显著性差异 (P>0 .0 5 )。两组不良反应发生率分别为 1.77% (1/ 6 0 )和 5 .0 0 % (3/ 6 0 ) ,无显著性差异。结论 在治疗下呼吸道感染中 。
Objective: To evaluate and compare the efficacy and safety of domestic cefuroxime and Zinacef . Methods: In this multicenter, randomized, prospective study, 60 patients received 1.5g of cefuroxime intravenously twice a day (treatment group), 60 patients received 1.5g of Zinacef twice a day (control group). Results: The overall efficacy rate of cefuroxime and Zinacef were 91.7% and 95.0% respectively ( P >0.05). The eradication rate for two groups were 95.2% and 100.0% respectively ( P >0.05). The adverse events rate were 1.77% and 5.00% ( P >0.05). Conclusion: Results indicate that for the majority of patients with lower respiratory tract infections, both the domestic cefuroxime and Zinacef are effective and safe.
出处
《中国抗生素杂志》
CAS
CSCD
北大核心
2001年第5期368-370,共3页
Chinese Journal of Antibiotics
