摘要
目的 :探讨胰高血糖素受体 (GCG R)基因外显子 2Gly40Ser突变是否与中国人迟发型非胰岛素依赖型糖尿病 (non -insulin -dependentdiabetesmillitus,NIDDM)相关。方法 :选择湖南地区汉族人NIDDM患者 82例及正常对照136例 ,应用聚合酶链反应———限制性片段长度多态分析方法 ,检测Gly40Ser突变。结果 :受检者均不存在Gly40Ser的错义突变。结论 :该突变不是引起中国人NIDDM的重要遗传因素。文献报道白种人GCG R基因Cly40Ser与NIDDM相关 。
Objective To ascertain whether Gly40Ser mutation in exon 2 of glucagon recepter (GCG R) gene is associated with late onset non insulin dependent diabetes millitus (NIDDM) in Chinese. Methods We selected 82 NIDDM patients and 136 controls of Han nationality in Hunan province, and detected Gly40Ser mutation using polymerase chain reaction restriction fragment length polymorphism (PCR RFLP). Results None of Gly40Ser mutation was found in all subjects. Conclusions The mutation doesn't associate with NIDDM in Chinese, even though the mutation was reported to be associated with NIDDM in certain French and Caucasians, genetic heterogeneity of NIDDM among ethnic groups should be considered.
出处
《湖南医科大学学报》
CSCD
北大核心
2001年第4期291-293,共3页
Bulletin of Hunan Medical University
基金
国家自然科学基金 ( 39896 2 0 0 )
973项目 (G19980 5 10 0 2 )
国家杰出青年科学基金 ( 395 2 5 0 12 )
国家自然科学基金 ( 39980 0 18)
2 0 0 0年高等学校全国优秀博士学位论文作者专项资金 ( 2 0 0 0 14 )
