摘要
目的 了解下呼吸道标本肺炎克雷伯氏菌、大肠埃希氏菌产超广谱 β-内酰胺酶 (ESBL s)的情况及耐药检测 ,供临床用药借鉴。方法 对 1999年 7月至 2 0 0 0年 7月期间我院临床下呼吸道标本分离 92 0株肺炎克雷伯氏菌 ,186株大肠埃希氏菌 ,用双纸片协同扩散法检测 ESBL s,用 Kirby- Bauer琼脂扩散法作药敏试验。结果 92 0株肺炎克雷伯氏菌中检出产 ESBL s菌 2 39株 ,检出率为 2 5 .98% ,186株大肠埃希氏菌中检出产 ESBL s菌 31株 ,检出率为 16 .6 7% ;除亚胺培南外 ,产 ESBL s菌对其它 9种抗生素的耐药率均显著高于非产 ESBL s菌 (P<0 .0 1) ;亚胺培南对产 ESBL s菌全部敏感。结论 肺炎克雷伯氏菌、大肠埃希氏菌中产ESBL s菌检出率高 ,且为多重耐药 ,亚胺培南是治疗 ESBL
Objecrive To investigate extended-spectrum β-lactamases (ESBLs) production and drug resistance test of Klebsiella pneumoniae and Escherichia coli in lower respiratory tract samples, and provide reference for clinical drug initiation. Methods 920 strains of Klebsiella pneumoniae and 186 strains of Escherichia coli isolated froim lower respiratory tract were collected from July. 1999 to July. 2000. Double-disk synergy test was used to detect ESBLs and Kirby-Bauer agar diffusion method was used to judge drug sensitivity. Results 239 strains of Klebsiella pneumoniae and 31 strains of Escherichia coli were considered ESBLs producers, detectable rates were 25.98% and 16.67% respectively. Except imipinem, the resistant rates of ESBLs-producing strains to other 9 antibiotics were much higher than that of non-ESBLs-producing strains (P< 0.01). The resistant rates of imipinem to ESBLs-producing strains were the lowest. Conclusions The detectable rates of ESBLs-producing strains in Klebsiella pneumoniae and Escherichia coli specimens isolated from lower respiratory tract were high. The ESBLs-producing strains were all multiple-drug resistant. Imipinem was the effective antibiotic to infections caused by ESBLs-producing strains.
出处
《中国抗生素杂志》
CAS
CSCD
北大核心
2001年第6期477-479,共3页
Chinese Journal of Antibiotics
