摘要
了解临床感染性疾病中常见的病原菌种类、分布及体外耐药谱 ,配合临床合理选药和有效治疗。方法 按《全国临床检验操作规程》进行。结果 从临床标本中分离了 6 197株细菌 ,其中铜绿假单胞菌 10 96株、大肠埃希氏菌 96 1株、金葡球菌 787株、表葡球菌 6 76株、克雷伯氏菌 393株 ,依次占分离率的 17.7%、15 .5 %、12 .7%、10 .9%、6 .3%。铜绿假单胞菌居首 ,其中铜绿假单胞菌主要来自痰标本 ,大肠埃希氏菌主要来自尿标本 ,金葡球菌主要来自分泌物标本。耐药性较高的有以下菌株 ,铜绿假单胞菌对庆大霉素、头孢唑林的平均耐药率分别为 5 1.2 %、72 .9% ;金葡球菌对青霉素的平均耐药率为 74.5 % ;表葡球菌对青霉素、苯唑西林及复方磺胺甲口恶唑片的平均耐药率分别为 6 8.2 %、6 6 .3%、73.4%。以上耐药率均超过 5 0 .0 %。结论 2 0世纪 90年代后期细菌检出率及耐药率都在迅猛增加 ,要加强对细菌的监测 ,指导临床合理用药 。
The prevalent pathogens and the in vitro drug resistance in our hospital in the 90s were investigated according to the 'National Clinical Laboratory Operation Manual'. Among the 6197 clinical isolates, 1096 strains were Pseudomonas aeruginosa , (mainly collected from sputum); 961 strains were E.coli (from urine); 787 strains were Stapbylococcus aureus (from secretion); 676 strains were S.epidermidis and 393 strains were Klebsiella pneumoniae . The isolation rates were 17.7%, 15.5% , 12.7%, 10.9% and 6.3% respectively. Most of the isolated strains showed higher drug resistance. The resistant rates are as follows: Ps.aeruginosa to gentamicin and cefazolin were 51.2% and 72.9%; S.aureus to penicillin was 74.5%; S.eidermidis to penicillin, oxacillin and compound sulfamethoxazde tablets were 68.2%, 66.3% and 73.4% respectvely. It was showed that the drug resistance during the 90s, especially in the latter period, was increased rapidly. This tendency is worthy to be considered by clinicians into the rational usage of antimicrobial agents to combat bacterial infections.
出处
《中国抗生素杂志》
CAS
CSCD
北大核心
2001年第6期447-450,共4页
Chinese Journal of Antibiotics
关键词
病原菌
琼脂扩散法
抗生素
耐药率
药敏试验
Pathogenic bacteria
Agar diffusion method
Antibiotic
Drug resistant rate
