摘要
收集40例单用苯妥英钠(DPH)治疗的癫痫病人,观察DPH对机体体液免疫和细胞免疫的影响及其与原发性免疫功能紊乱的关系。结果显示,癫痫病人免疫功能低于正常人,服用DPH可加重,服DPH达25～36个月时IgA有显著回升;原发IgA低下者服用DPH无影响,继发之药源性IgA缺乏者则有显著回升;原发性细胞免疫低下者服DPH无变化,继发者有轻度回升趋势;原发性与继发性癫痫均可有免疫功能紊乱。药源性免疫功能紊乱可能与抗痫药物影响机体整个免疫过程有关。
We observed the effect of single-drug treatment with phenytoin (DPH) on the humoral and cellular immunity, and DPH's relation with primary immune deficiency in 40 cases of epilepsy. We found that 1) the immune function of epileptics was much lower than that of normal controls, and could be aggravated by taking DPH;
2) the serum IgA increased significantly after 25～36 months of treatment with DPH; 3) patients with primary low levels of IgA showed no change after taking DPH, but those with drug-induced secondary low levels showed an increase of IgA; 4) patients with primary cellular immune deficiency showed no change after the use of DPH while
a slight tendency to elevated cellular immunity was seen in those with secondary i- mune deficiency; 5) both patients with primary epilepsy and those with secondary epilepsy might have abnormal immune function. Antiepileptic-drug-induced immune disorders may have resulted from the effect of the drugs on the whole immune proce-dure in the body
出处
《青岛医学院学报》
1991年第4期315-319,共5页
Acta Academiae Medicinae Qingdao Universitatis
关键词
苯妥英钠
癫痫
免疫
抗体
phenytoin
antibody formation
immunity, cellular
epilepsy
