摘要
用类固醇治疗900例重症肌无力患者,结果出现9例股骨头缺血性坏死,发生率为1%。男6例,女3例,年龄22～60岁。骨坏死的发生与开始3个月用类固醇的总量大小有关,而与总疗程无关。在开始3个月的总量<3.6g的725例患者中,无1例发生骨坏死者,而在≥3.6g的175例患者中骨坏死9例,高达5%,二者有显著性差异(P<0.001)。经1～12年的随访,发现早期停止用药可使病情稳定且偶见改善。早期作骨减压术可使症状消失。为防止这一合并症的发生,应尽量减少开始3个月激素的总量,特别是对30岁以上的患者尤其应引起重视。
Out of the 900 cases of myasthenia gravis treated at this hospital over thee
past 12 years, 9 developed avascular necrosis of the femoral head, the incidenc
being 1%. 6 of these patients were male and 3 were female, ranging in age from
22 to 60 years. The age of onset was mostly from 22 to 60. We found that the
development of this necrosis was related to the dosage of drug (prednisone)
administered during the first three months of treatment: the higher the dosage, the
greater the possibility of developing the necrosis, as all the above 9 patients were
among the 175 patients who received a total dosage of more than 3600mg during
the first three months, while none of the 725 patients who were given less than
that amount ever developed this complication. In order to prevent avascular necrosis
of the femoral head, steroid therapy for myasthenia gravis should be put under strict
supervision of the physician.
出处
《青岛医学院学报》
1991年第3期217-220,共4页
Acta Academiae Medicinae Qingdao Universitatis
关键词
重症肌无力
股骨坏死
药物疗法
femur head necrosis
myasthenia gravis
adrenal cortex hormones
drug therapy
