摘要
将呋喃唑酮、磺胺嘧啶和诺氟沙星各以 3种水平分别混入饲料中投喂甲鱼 (中华鳖Trionyxsinen sis) ,投药饵时间分别为 7d和 14d。停药后 2 4、72、12 0和 2 4 0h分别取血液、肝、肾和肌肉测定药物残留量。结果表明 ,呋喃唑酮的吸收量甚微 ,4种样品中均未检出残留 ,说明该药只适用于肠道疾病的防治 ;磺胺嘧啶在 4种样品中均可检出 ,在停药后 2 4h ,血液中含量最高 ,然后迅速降低 ,72h降至最低 ,2 4 0h则不能检出 ;诺氟沙星的药物残留变化状况与磺胺嘧啶相似。残留排除速度以肌肉中最慢 ,以停药 2 4h残留量为标准 ,停药 12 0h磺胺嘧啶残留率为 76.8% (1.65～ 2 .37μg/kg) ,诺氟沙星为 4 6% (0 .81～ 0 .93μg/kg) ;停药 2 4 0h则分别为 2 5 % (0 .63～ 1.11μg/kg)和 2 4 .2 % (0 .35～ 0 .4 4μg/kg)。血液、肝、肾和肌肉中的药物残留水平随给药量的增加而增加 ,给药时间的长短对血液中的药物浓度影响不大 ,但在肝、肾和肌肉中的药物残留则随给药时间的加长而显著增加 (P <0 .0 5 )。建议饲喂磺胺嘧啶或诺氟沙星的甲鱼应在停药 10d后上市。
The soft turtle, Trionyx sinensis, body weight 235～319g, were fed the diets containing furazolidone(10 -4 , 10 -3 , 3×10 -3 ), sulfadiazine(10 -4 , 10 -3 , 3×10 -3 ) or norfloxacin(10 -5 , 10 -4 , 3×10 -4 ), for 7 and 14 d respectively. The experiment water temperature was (30±1)℃. The blood and 3 other tissues, i.e.liver, kidney and muscle, were analyzed at hour 24, 72, 120 and 240 after withdraw medication. The results showed that furazolidone was absorbed too little to be detected; the residual sulfadiazine could be detected in the 4 samples but the highest level was observed in the blood at hour 24 after the withdraw, and then dropped rapidly to the lowest level at hour 72 and vanished at hour 240, and norfloxacin was the samilar case in its residual change. The effect of administered time was not obvious on residue level in blood but that's not the case in the other 3 tissues that the residual levels went up with the elapse of administered time (P<0.05). The residual elimination was the slowest in muscle that the residue rate was 76.8%(1.65～2.37 μg/kg) at hour 120 and 25%(0.63～1.11 μg/kg) at hour 240 for sulfadiazine, and for norfloxacin, 46%(0.81～0.93 μg/kg) at hour 120 and 24.2%(0.35～0.44 μg/kg) at hour 240 (the percentage was on the basis of the residue levels at hour 24 after withdraw). It is suggested that the sulfadiazine- or norfloxacin-treated soft turtle be onto the market 10 d after withdraw medication.
出处
《中国水产科学》
CAS
CSCD
北大核心
2001年第3期50-53,共4页
Journal of Fishery Sciences of China
基金
浙江省重点攻关项目资助 ( 99110 2 2 5 3 0 0 2 )
