摘要
目的研究碱性成纤维细胞生长因子 (bFGF)对颅脑损伤后神经行为学的影响及其有关机制。 方法将 30只SD大鼠随机分成正常组、假手术组、外伤对照组、bFGF治疗组和生理盐水对照组。建立大鼠侧方液压颅脑外伤模型 ,观察神经行为学 ,脑组织含水量 ,脑组织损伤面积及病理学变化。 结果与外伤对照组及生理盐水对照组相比 ,bFGF能促进神经功能的恢复 ,并降低脑组织的含水量 ,减少损伤面积 (P <0 .0 5 ) ,并能减轻颅脑损伤后的病理学损害。 结论bFGF有助于颅脑损伤后的神经行为学的恢复 ,其机制与减轻脑水肿 。
Objective To study the effect of bFGF on neuroethology in the head_injuried rats and the related mechanisms. Methods 30 SD rats were devided into the following groups:normal group, pseudo operative group, injuried control group, saline_treated control group and bFGF-treated group. By the parasagittal fluid-percussion model, the post traumatic neuroethology, water volume of brain tissue, contusion volume, and pathological findings of different groups were studied. Results Compared with the other groups, bFGF could enhanced the recovery of neuroethology, reduced the water volume and contusion volume of brain tissue, and abated the pathological damages to brain(P< 0.05). Conclusion These findings suggest that bFGF is helpful to the neuroethological recovery of traumatic brain by reducing the post traumatic brain edema and secondary neurological damages to the brain tissue.
出处
《上海第二医科大学学报》
CSCD
2001年第4期313-315,共3页
Acta Universitatis Medicinalis Secondae Shanghai
