摘要
lats基因 (largetumorsuppressorgene)最早在果蝇中发现 ,在小鼠和人中均有同源基因 .该基因的功能从果蝇到人是高度保守的 .lats基因的功能包括 :作为肿瘤抑制基因 ,其突变会导致肿瘤的发生 ;磷酸化的Lats与Cdc2结合 ,参与细胞周期的调控 ;通过细胞 细胞间的通讯 ,可能参与生物体个体大小的调控机制 .从果蝇到人lats基因功能的研究 。
lats gene (large tumor suppressor gene), first identified in Drosophila melanogaster, has its homologues in mouse and human. The function of lats is highly conserved from Drosophila to human. Its function includes: as a tumor suppressor gene, lats mutation will result in a tumor phenotype; phosphorylated Lats can bind to Cdc2 and regulate cell cycle; Lats may also be involved in size control mechanism via cell-cell communication. The study of lats function from Drosophila to human can provide a method to study gene functions in mammals using Drosophila as a model organism.
出处
《生物化学与生物物理进展》
SCIE
CAS
CSCD
北大核心
2001年第6期811-814,共4页
Progress In Biochemistry and Biophysics
