摘要
目的 探讨联合检测神经特异性烯醇化酶 (NSE)、癌胚抗原 (CEA)、肿瘤相关抗原 12 5 (CA12 5 )在肺癌诊断、疗效评价、转移复发监测中的应用价值。方法 应用微粒子酶联免疫分析法及生物素—链霉亲和素双抗体夹心法 ,分别对 30例健康人、4 8例肺良性疾病患者、5 0例非小细胞肺癌患者 (NSCLC)和 14例小细胞肺癌患者(SCLC)血清中NSE、CEA和CA12 5水平进行检测。结果 NSE和CEA二者在NSCLC和SCLC患者血清中水平均显著高于正常对照组和肺良性疾病组 (P <0 0 5 ) ,NSCLC患者血清CA12 5水平显著高于正常对照组和肺良性疾病组 (P <0 0 5 ) ,而在SCLC患者血清中水平与正常对照组和肺良性疾病组相比 ,差异无显著意义 (P >0 0 5 )。NSE、CEA、CA12 5检测NSCLC的敏感度分别为 4 2 3%、5 6 3%、63 2 % ,检测SCLC的敏感度分别为 68 2 %、4 4 4 %、2 9 5 % ,三者联合检测NSCLC和SCLC的敏感度分别为 84 2 %、78 5 % ,三者联合检测SNCLC和SCLC的敏感度大大提高 ,而三项指标单独检测和联合检测肺癌的特异性差异无显著性意义 (P >0 0 5 )。结论 NSE、CEA、CA12 5三项指标在肺癌的早期诊断、疗效观察及转移复发监测中有重要意义 ,三项指标联合检测可提高对肺癌的诊断价值。
Objective To study the clinical significance of neuron specific enolase (NSE),carcinoembryonic antigen(CEA) and carcinoma associated antigen(CA125) in diagnosis,evaluation of therapy and monitoring metastasis and recurrence of lung cancer.Methods The levels of NSE,CEA and CA125 were detected in the sera from 30 healthy controls,48 patients with benign diseases,50 patients with non-small cell lung cancer(NSCLC) and 14 patients with small cell lung cancer(SCLC) by using microparticle enzyme linked immunoassay and bioantibodies sandwich one step assay by using streptavidin technique,respectively.Results The levels of NSE and CEA in the sera of patients with NSCLC and SCLC were significantly higher than those of healthy controls and patients with benign diseases (both P<0 05),the levels of CA125 in the sera of patients with NSCLC was significantly higher than those of healthy controls and patients with benign diseases(both P<0 05),but no significantly difference was found among the patients with SCLC and healthy controls and patients with benign disease(P>0 05).The levels of NSE CEA and CA125 decreased after the treatment and increased greatly with the metastasis and recurrence of the cancer.After the combination of NSE and CEA and CA125,the sensitivity significantly increased,but no difference was found in the specifity.Conclusion Measuring serum levels of NSE,CEA and CA125 are very useful in diagnosis,evaluation of therapy and monitoring of metastasis and recurrence of lung cancer.
出处
《中国医师杂志》
CAS
2001年第11期831-833,共3页
Journal of Chinese Physician
关键词
肿瘤标记
肺癌
诊断
治疗
Tumor markers
Lung,carcinoma
Diagnosis
Therapeutic,effectiveness
