摘要
目的 比较卡托普利与依那普利对原发性高血压的降压疗效和安全性。 方法 1,2级原发性高血压患者 5 0例 ,随机分为卡托普利组 (n =2 5 )与依那普利组 (n =2 5 ) ,分别口服卡托普利37 5mg～ 75mg/天和依那普利 10mg～ 2 0mg/天 ,治疗 4周。 结果 卡托普利组SBP/DBP下降 17/12mmHg(P <0 0 1) ,依那普利组SBP/DBP下降 2 1/ 13mmHg(P <0 0 1)。卡托普利组总有效率 80 %与依那普利组 84%相似。两组用药前后电解质、血糖及血脂均无明显变化。 结论 依那普利治疗高血压的疗效与对照药卡托普利相似 ,其疗效确切 ,不良反应少 ,耐受性好。
Objective To compare the effect of captopril and enalapril in treatment of hypertension Methods Fifty hypertensive patients were randomly divided into two groups The captopril group were given captopril 37 5～75mg/day,while the enalapril group were given enalapril 10～20mg/day for four weeks Results SBP/DBP for the captopril group decreased to 17/12mmHg(P<0 01);and the enalapril group 21/13mmHg(P<0 01) The effective rate was 80% in the captopril group and 84% in the enalapril group There is no significant difference between the two groups for electrolyte,blood sugar,serum cholesterol,or triglyceride Conclusion The effect of enalapril is similar to captopril Enalapril only had fewer side effects
出处
《实用心脑肺血管病杂志》
2001年第4期202-203,共2页
Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease
