摘要
目的 探讨乙肝病毒 (HBV)前S1(PreS1)蛋白对孕妇及婴儿的影响。方法 孕妇分别在孕早期、孕中期、孕晚期及分娩时共采血四次 ,婴儿出生后1个月至1个半月间抽血一次。每次血均测定PreS1蛋白和乙肝三系。结果 300例孕妇中受乙肝病毒感染者29人 (9.6 % ) ,PreS1蛋白阳性者19人 (6.3 % ) ,HBeAg阳性者12人 ,其中11人伴有 preS1蛋白阳性 ,婴儿受感染者18例 (6 % ) ,其中母亲PreS1蛋白阳性者14例 (77.8% )。结论 PreS1蛋白与HBeAg具有一致性 ,PreS1蛋白阳性 ,特别是孕晚期阳性 ,容易通过围产期传给婴儿。
Objective To discuss how hepatitis B virus (HBV) infect the pregnant women and their infants. Methods The pregnant women were phlebotomized during the earlier, middle, later stage of pregnancy and parturition. Their infants were phlebotomized one month or one and half month after nativity. PreS1 protein, HBeAg et al of HBV was detected. Results In 300 pregnant women, 29 (9.6%) were HBV infectors, 19 with positive PreS1 protein, 12 with positive HBeAg. 11 cases showed the coexistence of PreS1 protein and HBeAg. 18 infants were infected by HBV, 14 of their mother with positive PreS1 protein. Conclusion There was concordance between PreS1 protein and HBeAg. To those with positive PreS1 protein in late trimester of pregnancy, HBV would easily be spread vertically to infants.
出处
《浙江临床医学》
2001年第9期629-630,共2页
Zhejiang Clinical Medical Journal
