摘要
目的 观察老年单纯收缩期高血压 (ISH)患者血浆神经肽Y(NPY)浓度的变化 ,并探讨其临床意义。方法 采用放射免疫法测定 40例ISH患者血浆NPY浓度 ,其中 30例应用彩色多普勒超声心动图仪测定左室射血分数。结果 (1)ISH患者NPY浓度较正常对照组明显升高 (P <0 .0 1)。且NPY的浓度与收缩压增高的幅度呈正相关。(2 )ISH患者血浆NPY浓度 1级最低 ,2级居中 ,3级最高 ,各级之间差异有显著性意义 (F =6 7.5 8,P <0 .0 1)。(3)血浆NPY浓度随心功能损害程度加重而上升 (F=5 9.6 8,P <0 .0 1)。结论 NPY可能参与高血压的发生和发展 ,并与病情有关。
Objective To investigate the change of plasma neuropeptide Y(NPY)levels in elderly patient with isolated systolic hypertension(ISH) and its clinical significance.Methods The plasma NPY level was measured by radioimmunoassay in 40 elderly patients with ISH and 23 normal controls.Ventricular ejection fractions(EF) were determined in 30 cases of the 40 elderly patients with ISH.Results (1)The plasma NPY level was significantly higher in elderly patients with ISH than in normal control persons(P<0.01). The NPY levels were positively correlated with systolic blood pressure(r=0.35,P<0.05).(2)The ISH patients of stage Ⅰ had the lowest plasma NPY level,while those of the stage Ⅱ had the median and those of the stage Ⅲ had the highest levels (F=59.68,P<0.01).(3) Plasma NPY levels increased with increase in severity of heart failure in elderly patients with ISH(F=26.25,P<0.01).Conclusions There was significant relationship between plasma NPY and the severity of hypertension.NPY may serve as an index to assess the severity of the disease in elderly patients with ISH.
出处
《中华老年心脑血管病杂志》
CAS
2001年第5期305-307,共3页
Chinese Journal of Geriatric Heart,Brain and Vessel Diseases
