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CD147与子宫内膜异位症的相关性研究 被引量：3

Expression of CD147 in endometriosis
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摘要 目的 :探讨和比较免疫球蛋白超家族分子CD147在子宫内膜异位症患者异位子宫内膜、在位子宫内膜及健康人子宫内膜中表达及定位。方法 :采用免疫组化方法对 30例异位子宫内膜及其 18例同期在位子宫内膜和 15例健康人子宫内膜组织中的CD147的表达进行观察。结果 :异位子宫内膜标本中CD147表达增强 ,以膜分布为主 ;而无论有无子宫内膜异位症 ,在位子宫内膜中CD147表达无差异。结论 :CD147分子表达在异位子宫内膜和正常子宫内膜存在明显差异。CD147可能与子宫内膜异位症的发生密切相关。 Objective:To evaluate the expression and localization of CD147 in endometriosis Methods: The expression of CD147 protein on paraffin embeded tissues was determined by immunohistochemical analysis endometriotic tissues ( n =30) and matched eutopic endometria( n =18) of patients with endometriosis and eutopic endometria of normal menstruating women without endometriosis( n =15) Results:Endometriotic tissues showed statisticaly stronger staining compared with eutopic endometria( P <0 05) Conclusion: Compared to eutopic endometrium,ectopic endometrium has a higher capacity to produce CD147
作者 王丽 李亚里 田方 孟元光 肖凤君 许道江
机构地区 解放军总医院妇产科 军事医学科学院附属医院肿瘤分子生物室
出处 《军医进修学院学报》 CAS 2001年第4期306-307,共2页 Academic Journal of Pla Postgraduate Medical School
基金 国家自然科学基金资助项目 ( 39830 35 0 )
关键词 子宫内膜异位症 免疫球蛋白类 免疫组织化学 CD147 endometriosis immunoglobulins immunohistochemical
分类号 R711.71 [医药卫生—妇产科学]
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参考文献5

  • 1[1]Starzinski A,Gaetje R,Zeitvogel A. Tracing cellular and molecular mechanisms involved in endometriosis [J]. Hum Reprod Update 1998,4(5):724-729.
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  • 3[3]Guo H, Li R, Zucker S, et al. EMMPRIN( CD147 ),an inducer of matrix metalloproteinase synthesis, also binds intcrstitial collagcnasc to the tumor cell surface [J]. Cancer Res,2000, 60: 4,888-891.
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同被引文献26

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军医进修学院学报
2001年 第4期

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