摘要
目的:减少因样品降解而对含量分析结果产生影响。方法:按照中国药典2000年版中阿莫西林克拉维酸钾片的含量测定方法。结果:在24 h时,阿莫西林含量下降情况(在水溶液中为8.08％,在醋酸-醋酸钠缓冲液中为2.39％),克拉维酸含量下降情况(在水溶液中为11.28％,在醋酸-醋酸钠缓冲液中为4.25％)。结论:为了得到准确的含量分析结果,必须严格控制分析时间,快速处理样品。
Objectives: To decrease the degradation of sample on an influence produced by the result of content analysis. Method: The content determination method from amoxacillin/potassium clavulanate tablet in China Pharmacopeia 2000 was used. Result: At 24 hr, amoxacillin content declined by 8. 08% and 2. 39% in aqueous solution and buffer solution of acid acetic and sodium acetate, respectively. Conclusion: It is suggested that the determining method for this drug in China Pharmacopeia should be used for obtaining a accurate result of content analysis.
出处
《中国药师》
CAS
2001年第4期270-272,共3页
China Pharmacist
