摘要
目的:研究肝肾疾病、癌症及糖尿病患者血浆纤维蛋白原水平与功能,并探讨其临床意义。方法:用蕲蛇酶水解纤维蛋白原,用计算机自动检测系统测定。用纤维蛋白单体聚合反应速率(FMPV)、最大吸光度(Amax)、凝固性纤维蛋白原含量(S)、功能指标(FI=FMPS/Amax)、反应延滞时间(DT)表示。结果:癌症组除DT缩短,余各项指标均增高;肝病组各项指标均降低,DT缩短;肾功能衰竭、糖尿病(NIDDM)多项指标增高。结论:纤维蛋白原水平与功能检测提示肝病患者为低凝状态,而肾脏疾病、癌症、糖尿病患者则为高凝状态。
Objective: To detect plasma level and function of fibrinogen(Fbg) in patients with hapatic-nephrotic disease, carcinoma, diabetes mellitus and discuss its clinical significance. Methods: Acutulase hy-drolyzed Fbg and calculator automatic detection system were use for fibrin attraction luminosity(Amax), fibrinogen concentration(s) , reaction delayed time(DT) and function index(FI=FMPV/Amax). Results: , Carcinoma detected value were increase expect DT, hepatic disease detect value were decreased Dt lower than control. Nephritic disease and diabetes were increased in all detect index. Conclusion: Detection Fbg level and function showed that patients with hepatic disease were low coagulation state, hephrotic disease (chronic renal insufficiency), diabetes and carcinoma showed high coagulation state. Therefore, we should take measure to combat the hemostasis thrombosis.
出处
《血栓与止血学》
2001年第4期163-165,共3页
Chinese Journal of Thrombosis and Hemostasis
关键词
纤维蛋白原
肝肾疾病
癌症
糖尿病
Fibrinogen Hepatic-nephrotic disease Carcinoma Diabetes mellitus
