摘要
目的 比较ⅠA和ⅠB期非小细胞肺癌 (NSCLC)患者术后远期生存率的差异 ,分析影响Ⅰ期NSCLC患者术后远期生存率的因素。方法 回顾性分析我科在 1 974～ 1 995年期间手术治疗的 96例Ⅰ期NSCLC病例 ,对患者的性别、年龄、T分级、原发肿瘤大小、脏层胸膜侵犯、切除方式、肿瘤病理类型、分化程度和位置共 9个可能影响术后远期生存率的因素进行了单因素和多因素分析。结果 ⅠA和ⅠB期NSCLC患者术后 5年生存率有显著性差异 (P <0 .0 5 ) ,单因素分析提示T分级、原发肿瘤大小、脏层胸膜侵犯、肿瘤分化程度对Ⅰ期NSCLC患者术后 5年生存率有显著性影响 (P <0 .0 5 ) ,但多因素分析提示只有脏层胸膜侵犯和肿瘤分化程度是独立预后因素 (P <0 .0 5 )。结论 Ⅰ期NSCLC可进一步分成ⅠA和ⅠB两个亚期 ,两个亚期间5年生存率存在显著性差异 ,脏层胸膜侵犯和肿瘤分化程度是影响Ⅰ期NSCLC患者术后 5年生存率的独立预后因素。
Objective To compare the postoperative survival difference between stage ⅠA and ⅠB non small cell lung cancer (NSCLC) and analyze the prognostic factors affecting the long term survival of resected stage Ⅰ NSCLC. Methods Ninety six patients with stage Ⅰ NSCLC surgically treated in our department from 1974 to 1995 were studied retrospectively. Nine possible prognostic factors including gender, age, T grade, primary tumor size, visceral pleural involvement, type of resection, pathological type, tumor differentiation, and location were analyzed by univariate analysis and multivariate analysis subsequently. Results There was a significant difference in postoperative 5 year survival between stage ⅠA and ⅠB (P<0.05). The significant prognostic factors (P<0.05) demonstrated by univariate analysis included T grade, primary tumor size, visceral pleural involvement and tumor differentiation, while visceral pleural involvement and tumor differentiation served as the independent prognostic factors (P<0.05) with multivariate analysis. Conclusion Stage Ⅰ NSCLC should be subdivided into ⅠA and ⅠB whose five year survival was proved to be significantly different. Visceral pleural involvement as well as tumor differentiation played as the independent prognostic factors in resected stage Ⅰ NSCLC.
出处
《中国肺癌杂志》
CAS
2001年第6期431-434,共4页
Chinese Journal of Lung Cancer
