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阿波莫斯治疗肝性脑病疗效观察 被引量:3

Effect of hepa-mers in the treatment of hepatic encephalopathy
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摘要 目的 观察阿波莫斯在肝性脑病治疗中的疗效。方法 把 146例不同程度的肝性脑病患者随机分成两组 ,分别给予阿波莫斯及乙酰谷酰胺治疗 ,定期观察患者神志、扑翼样震颤 ,并对其中 84例血NH3 升高者进行血NH3 监测 ,用 χ2 检验和t检验分析结果。结果 阿波莫斯能显著地改善肝性脑病患者的神志、扑翼样震颤 (P <0 0 5 )及降低血NH3(P <0 0 5 )。结论 阿波莫斯在肝性脑病治疗中有明显疗效。 AIM To observe the effect of hepa\|mers in the treatment of hepatic encephalopathy. METHODS 146 patients with hepatic encephalopathy. Were divided into two groups randomly and treated by hepa-mers and aceglutamide respectively, they were observed with consciousness and flapping tremor regularlyl; and 84 cases with high blood amonia were monitored, the results were analysed by chi-square test and significance test. RESULTS Hepa\|mers apparently improves patients consciousness and flapping tremor ( P< 0 05) and lowers the blood amonia ( P< 0 05) compared with aceglutamide. CONCLUSION Hepa\|mers has marked effect in the treatment of hepatic encephalopathy.
出处 《安徽医药》 CAS 2001年第2期98-99,共2页 Anhui Medical and Pharmaceutical Journal
关键词 阿波莫斯 乙酰谷酰胺 肝性脑病 血NH3 hepa\|mers aceglutamide hepatic encephalopathy blood amonia
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  • 1Takahashi H, Koehler RC, Brusilow SW et al. Inhibibion of brain glutamine accumulation prevents cerebral edema in hyperammonemic rats. Am J Physiol, 1991;261:825~9
  • 2Gebhardt R, Reichen J. Changes in destribution and activity of glu-tamine synthetase in CCL4-induced liver cirrhosis in the rat: potential. ro in hyperammonemia. Hepatology, 1994;20:684~91
  • 3Stoll B, Mc Nelly S, Buscher HP et al. Functional hepatocyte heterogeneity in glutamate, aspartate and a-ketoglutarate uptake: a his toautoradiographical study. Hepatology, 1991; 13:247~53
  • 4Jessy J, Mans AM, De Joseph MR et al. Hawkins RA-Hyperammonemia causes many of the changes found after portocaval shunting. BiochemJ, 1990;272:311~7

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