摘要
通过心外膜电图标测、Swan-Ganz导管监测血流动力学及硝基四氮唑染色等方法,比较了硝酸甘油、前列腺素E_1、心得安对急性心肌梗塞范围(IS)和血流动力学的影响。结果表明,三者均能缩小IS,降低各标测点ST段抬高总和和以ST段抬高≥2mV的标测点数,对心输出量、每搏指数、心脏指数、肺毛细血管楔嵌压、心率的影响各不相同,前列腺素E_1既能缩小IS,又有良好的血流动力学效应。
The comparison of effects of nitroglycerin, prostaglandin E_1 (PGE_1) and propranolol on infarction size (IS) and hemodynamics during acute myocardial infarction (AMI) were studied by epicardial mapping, N-BT evalution and Swan-Ganz catheterization, etc. The results showed that nitroglycerin, PGE_1 and propranolol all diminish IS, decline ∑ST and NST. However, their effects on CO, SI, CI, PCWP and HR varied differently, POE_1 not only diminished IS but also showed better hemodynamic effects.
关键词
硝酸甘油
前列腺素E1
心肌缺血
Nitroglycerin
Prostaglandin E_1
Propranolol
Infarction size
Hemodynamics
Dog
