摘要
目的 :探讨老年大鼠胃大部切除围手术期血小板表面Ⅱb/Ⅲa受体的动态变化。方法 :成年大鼠 16只 ;老年大鼠 16只。分别制成胃大部切除模型 ,以PE标记的CD6 1荧光抗体流式细胞技术检测术前及术后 72h内血小板表面Ⅱb/Ⅲa受体的变化。结果 :老年组术后 6、12、2 4、48、72h各时点血小板表面Ⅱb/Ⅲa受体密度均较术前升高。结论 :血小板表面Ⅱb/Ⅲa受体密度增高 ,可能是老年大鼠胃大部切除术围手术期血栓前状态形成的重要原因之一。
Aim: To investigate changes of density of platelet glycoprotein ( GP)Ⅱb/Ⅲa receptor in the perioperative period of gastrectomy in aged rats. Methods:The subtotal gastrectomy operation was performed in 16 adult rats and 16 aged rats respectively. Platelet surface density of GPⅡb/Ⅲ receptors were determined by flow cytometric analysis before and 6,12,24,48,72 hours after operation. Results: 6,12,24,48 and 72 hours after operation,the density of GPⅡb/Ⅲa in aged group increased continuously compared with preoperative period (6h,12,72: P < 0.05 ;24,48: P <0.01). Conclusion: gastrectomy can lead to an increase of density of platelet GPⅡb/Ⅲa receptor in aged rats.
出处
《中国应用生理学杂志》
CAS
CSCD
北大核心
2001年第4期396-397,共2页
Chinese Journal of Applied Physiology
基金
全军"九五"医学科研重点课题 ( 96Z0 5 4)
