摘要
目的探讨 HLA-DR 抗原和热休克蛋白70(HSP70)在肝细胞癌(HCC)中的表达及其意义.方法采用免疫组化技术对44例 HCC 和癌旁组织中 HLA-DR 抗原和 HSP70的表达进行检测.结果癌旁正常肝组织中肝细胞未见 HLA-DR 抗原表达.HCC中肿瘤细胞 HLA-DR 抗原表达阳性率为43%.HCC 中 HSP70阳性率明显高于癌旁组织(阳性率分别为68%和27%,X^2=7.3,P<0.01).HLA-DR 抗原和 HSP70表达与癌周淋巴细胞浸润(X_1~2=0.51,X_2~2=3.2,P>0.05)和转移(X_1~2=2.9,X_2~2=2.3,P>0.05)无关,但与癌组织分化程度有关(X_1~2=4.9,X_2~2=4.5,P<0.05).结论 HLA-DR 抗原和 HSP70的异常表达在 HCC 发生、发展中起重要作用,对判断患者预后有一定的价值.
AIM To invetstigate the expression and significance of HLA-DR antigen and heat shock protein70(HSP70)in hepatocellular carcinoma(HCC). METHODS HLA-DR antigen and HSP70 were determined in specimens of 44 cases of HCC and tumor-surrounding tissues by immunohistochemistry. RESULTS HLA-DR antigen was not detected in hepatocytes tumor-surrounding tissues.The positive rates of HLA-DR antigen was 43% in tumor cells of HCC. The positive rate of HSP70 in HCC was higher than that in tumor-surrounding tissues(68% vs 27%,X^2=7.3,P<0. 01).Expression of HLA-DR antigen and HSP70 were not associated with tumor lymphocyte infiltration (X_1~2=0.51, X_2~2=3.2,P>0.05)and tumor metastasis histological grade(X_1~2=2.9,X_2~2=2.3,P>0.05),but they were associated with histological grade(X_2~2=4.9,X_2~2=4.5,P <0.05). CONCLUSIONS Expression of HLA-DR antigen and HSP70 may play an important role in genesis and development of HCC,and it is helpful to evaluate the prognosis of HCC patient.
出处
《世界华人消化杂志》
CAS
2001年第10期1139-1142,共4页
World Chinese Journal of Digestology
关键词
代谢
肝细胞癌
HLA-DR抗原
生物合成
热休克蛋白质类70
免疫组织化学
liver neoplasm/metabolism
carcinoma
hepatocellular/metabolism
HLA-DR antigen/biosynthesis
heat-shock proteins 70/biosynthesis
immunohistochemistry
