摘要
目的 :观察加速超分割放疗和化疗综合治疗老年晚期肺癌的耐受性 ,急性副反应和近期疗效。方法 :治疗组采用小剂量化疗 +放疗 +小剂量化疗根据组织细胞类型常规分割或超分割放疗、先化疗后对原发病灶、纵膈、肺门淋巴结及局部常规剂量照射。结果 :两组相比近期疗无明显差异 (P >0 .0 5 ) ,但血液学毒性 ,消化道反应差异显著 (P <0 .0 5 ) ,治疗组的食管炎 ,放射性肺炎虽有发生 ,但不严重 ,且无明显脱发现象 ,显示该组有较好的耐受性。结论 :加速超分割放疗和化疗综合治疗老年晚期肺癌能被患者耐受 ,主要的急性副反应为放射性食管炎 ,无严重早期反应 ,有较好的近期疗效 。
Objective:To investigate the feasibility,toxicity and the efficacy of concurrent low dosage chemotherapy plus twice daily thoracic radiotherapy in oldly advanced lung cacner.Methods:65 patients were collected and divided into two groups,patients in the treatment group treated with cisplatin 20mg days 1～5,HCPT 5～10mg days 1～5 at 3～4 weeks inlervals for 2～4 cycles;and received 69.6Gy irradiate in two daily fraction (1.2Gy).Patients in control group received chemytherapy cisplatin 30mg days 1～5,HCPT 5～10mg days 1～5,days 1～5,etoposide 100mg days1～5 at 3～4 weeks intervals for six cycles.Results:Two groups had no complete respoes,the partial response rate (PR)of two groups were 31.3% nd 27.2% respectively ( P >0.05).The acute side effects of gastrointestinal and hemalotogic toxicity were significant difference.Conclusions:Concurrent low dosage chemotherapy plus twicedaily thoracic radiotherapy in older patients of advanced lung cancer could be weel tolerated.The immediate response was encouraging.
出处
《中国现代医学杂志》
CAS
CSCD
2001年第8期9-10,共2页
China Journal of Modern Medicine
关键词
肺肿瘤
肺癌
加速超分剂放疗
化学治疗
同期化疗
Lung Cancer advanced lung
Cancer accelerated hyperfractionated radiotherapy chemotherapy concurent treatment
